Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1689996..1690585 Replicon chromosome
Accession NZ_AP018783
Organism Haemophilus influenzae strain CHBN-V-3 isolate 15H03

Toxin (Protein)


Gene name hicA Uniprot ID O87469
Locus tag K6J71_RS08405 Protein ID WP_005668369.1
Coordinates 1690337..1690585 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9R3J9
Locus tag K6J71_RS08400 Protein ID WP_005668366.1
Coordinates 1689996..1690340 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J71_RS08385 (CHBNV3_16160) 1685634..1688147 - 2514 WP_005668359.1 fimbria/pilus outer membrane usher protein -
K6J71_RS08390 (CHBNV3_16170) 1688242..1688940 - 699 WP_032826232.1 fimbria/pilus periplasmic chaperone -
K6J71_RS08395 (CHBNV3_16180) 1689261..1689899 + 639 WP_005668364.1 fimbrial protein -
K6J71_RS08400 (CHBNV3_16190) 1689996..1690340 - 345 WP_005668366.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J71_RS08405 (CHBNV3_16200) 1690337..1690585 - 249 WP_005668369.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J71_RS08410 (CHBNV3_16210) 1690756..1691250 + 495 WP_005664624.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J71_RS08415 (CHBNV3_16220) 1691320..1692408 + 1089 WP_005668373.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J71_RS08420 (CHBNV3_16230) 1692548..1693738 + 1191 WP_020910100.1 amino acid aminotransferase -
K6J71_RS08425 1693821..1693949 - 129 Protein_1623 hydrogenase expression/formation protein HypE -
K6J71_RS08430 (CHBNV3_16240) 1693959..1694576 - 618 WP_005667285.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J71_RS08435 (CHBNV3_16250) 1694578..1695210 - 633 WP_005667287.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9455.95 Da        Isoelectric Point: 10.4673

>T32235 WP_005668369.1 NZ_AP018783:c1690585-1690337 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLTQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32235 NZ_AP018783:c1690585-1690337 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AACTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.08 Da        Isoelectric Point: 5.0113

>AT32235 WP_005668366.1 NZ_AP018783:c1690340-1689996 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Download         Length: 345 bp

>AT32235 NZ_AP018783:c1690340-1689996 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCGATTAAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DKW8

Antitoxin

Source ID Structure
AlphaFold DB A0A806E3Y3

References