Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1041736..1042342 Replicon chromosome
Accession NZ_AP018783
Organism Haemophilus influenzae strain CHBN-V-3 isolate 15H03

Toxin (Protein)


Gene name hicA Uniprot ID A0A2V0SD64
Locus tag K6J71_RS05285 Protein ID WP_005667742.1
Coordinates 1041736..1041912 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A806ED58
Locus tag K6J71_RS05290 Protein ID WP_005642973.1
Coordinates 1041941..1042342 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J71_RS05245 (CHBNV3_10120) 1036780..1037283 + 504 WP_015967400.1 hypothetical protein -
K6J71_RS05250 (CHBNV3_10130) 1037302..1037670 + 369 WP_005667757.1 hypothetical protein -
K6J71_RS05255 (CHBNV3_10140) 1037670..1037855 + 186 WP_005667755.1 hypothetical protein -
K6J71_RS05260 (CHBNV3_10150) 1037867..1038148 + 282 WP_015967401.1 hypothetical protein -
K6J71_RS05265 (CHBNV3_10160) 1038199..1038459 + 261 WP_005667751.1 hypothetical protein -
K6J71_RS05270 (CHBNV3_10170) 1038462..1040789 + 2328 WP_005667749.1 replication endonuclease -
K6J71_RS05275 (CHBNV3_10180) 1040801..1041112 + 312 WP_005667746.1 hypothetical protein -
K6J71_RS05280 (CHBNV3_10190) 1041122..1041640 + 519 WP_005667744.1 phage N-6-adenine-methyltransferase -
K6J71_RS05285 (CHBNV3_10200) 1041736..1041912 + 177 WP_005667742.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J71_RS05290 (CHBNV3_10210) 1041941..1042342 + 402 WP_005642973.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J71_RS05295 (CHBNV3_10220) 1042369..1042629 - 261 WP_071819916.1 ogr/Delta-like zinc finger family protein -
K6J71_RS05300 (CHBNV3_10230) 1042708..1043745 - 1038 WP_005667739.1 phage portal protein -
K6J71_RS05305 (CHBNV3_10240) 1043735..1045558 - 1824 WP_015967402.1 terminase ATPase subunit family protein -
K6J71_RS05310 (CHBNV3_10250) 1045762..1046655 + 894 WP_005667735.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6632.65 Da        Isoelectric Point: 10.3659

>T32233 WP_005667742.1 NZ_AP018783:1041736-1041912 [Haemophilus influenzae]
VDSKTAIKMIEEDGWYLDRVKGSHHQYKHPTKKGTVTIPHPRKDLGHLEKSIKKQAGL

Download         Length: 177 bp

>T32233 NZ_AP018783:1041736-1041912 [Haemophilus influenzae]
GTGGATAGCAAAACAGCAATAAAAATGATAGAAGAGGACGGTTGGTATTTAGATAGAGTTAAAGGTAGTCATCATCAATA
CAAACATCCTACAAAAAAGGGAACGGTCACGATTCCCCACCCAAGGAAAGACTTGGGGCATTTAGAAAAAAGCATTAAAA
AACAAGCGGGGCTGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14922.06 Da        Isoelectric Point: 4.3937

>AT32233 WP_005642973.1 NZ_AP018783:1041941-1042342 [Haemophilus influenzae]
MLYPICIEKVNDGYVVSVPDVPGCFSAGDTLSEAMLNAKEAISFHIEGMLEDDEELPKSNPIEQYINQPEYKDFIVTVVD
VDLTHLMGKAEKINITVPALLLHRIDQFIATHPEYKNRSNFLSQLATNRLLSA

Download         Length: 402 bp

>AT32233 NZ_AP018783:1041941-1042342 [Haemophilus influenzae]
ATGTTATACCCGATTTGTATCGAAAAAGTAAATGATGGTTATGTGGTATCTGTGCCAGATGTGCCAGGCTGTTTTTCTGC
TGGGGATACCTTATCAGAAGCGATGTTAAACGCAAAAGAAGCAATCTCTTTTCACATTGAAGGGATGTTAGAAGATGATG
AAGAATTGCCTAAATCTAACCCAATAGAACAATATATTAATCAGCCCGAATATAAAGATTTTATTGTCACTGTTGTTGAT
GTAGATTTAACTCATTTAATGGGTAAGGCAGAAAAAATTAATATTACGGTTCCAGCGTTATTACTGCACCGCATTGATCA
GTTTATTGCCACCCATCCAGAATATAAGAATAGAAGTAACTTTTTGTCTCAACTAGCAACAAATAGATTACTTTCTGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V0SD64

Antitoxin

Source ID Structure
AlphaFold DB A0A806ED58

References