Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 369892..370496 Replicon chromosome
Accession NZ_AP018783
Organism Haemophilus influenzae strain CHBN-V-3 isolate 15H03

Toxin (Protein)


Gene name relE Uniprot ID A0A837MVY4
Locus tag K6J71_RS01905 Protein ID WP_050846512.1
Coordinates 369892..370200 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag K6J71_RS01910 Protein ID WP_005692346.1
Coordinates 370200..370496 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J71_RS01895 (CHBNV3_03600) 365009..366307 - 1299 WP_075985659.1 trigger factor -
K6J71_RS09630 366608..366729 + 122 Protein_363 PT domain-containing protein -
K6J71_RS01900 (CHBNV3_03610) 366675..369833 + 3159 WP_221282172.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
K6J71_RS01905 (CHBNV3_03620) 369892..370200 - 309 WP_050846512.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J71_RS01910 (CHBNV3_03630) 370200..370496 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J71_RS01915 (CHBNV3_03640) 370616..371470 - 855 WP_075985658.1 DUF3298 domain-containing protein -
K6J71_RS01920 (CHBNV3_03650) 371489..373348 - 1860 WP_075985657.1 selenocysteine-specific translation elongation factor -
K6J71_RS01925 (CHBNV3_03660) 373345..374730 - 1386 WP_075985656.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11920.68 Da        Isoelectric Point: 7.8657

>T32228 WP_050846512.1 NZ_AP018783:c370200-369892 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T32228 NZ_AP018783:c370200-369892 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT32228 WP_005692346.1 NZ_AP018783:c370496-370200 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT32228 NZ_AP018783:c370496-370200 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837MVY4

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References