Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1542963..1543552 Replicon chromosome
Accession NZ_AP018782
Organism Haemophilus influenzae strain CHBN-V-2 isolate 13H37

Toxin (Protein)


Gene name hicA Uniprot ID O87469
Locus tag K6J59_RS07625 Protein ID WP_005668369.1
Coordinates 1543304..1543552 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9R3J9
Locus tag K6J59_RS07620 Protein ID WP_005668366.1
Coordinates 1542963..1543307 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J59_RS07605 (CHBNV2_14560) 1538601..1541114 - 2514 WP_005668359.1 fimbria/pilus outer membrane usher protein -
K6J59_RS07610 (CHBNV2_14570) 1541209..1541907 - 699 WP_032826232.1 fimbria/pilus periplasmic chaperone -
K6J59_RS07615 (CHBNV2_14580) 1542228..1542866 + 639 WP_005668364.1 fimbrial protein -
K6J59_RS07620 (CHBNV2_14590) 1542963..1543307 - 345 WP_005668366.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J59_RS07625 (CHBNV2_14600) 1543304..1543552 - 249 WP_005668369.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J59_RS07630 (CHBNV2_14610) 1543723..1544217 + 495 WP_005664624.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J59_RS07635 (CHBNV2_14620) 1544287..1545375 + 1089 WP_005668373.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J59_RS07640 (CHBNV2_14630) 1545515..1546705 + 1191 WP_020910100.1 amino acid aminotransferase -
K6J59_RS07650 (CHBNV2_14640) 1546926..1547543 - 618 WP_005667285.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J59_RS07655 (CHBNV2_14650) 1547545..1548177 - 633 WP_005667287.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9455.95 Da        Isoelectric Point: 10.4673

>T32226 WP_005668369.1 NZ_AP018782:c1543552-1543304 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLTQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32226 NZ_AP018782:c1543552-1543304 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AACTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.08 Da        Isoelectric Point: 5.0113

>AT32226 WP_005668366.1 NZ_AP018782:c1543307-1542963 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Download         Length: 345 bp

>AT32226 NZ_AP018782:c1543307-1542963 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCGATTAAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DKW8

Antitoxin

Source ID Structure
AlphaFold DB A0A806E3Y3

References