Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 603825..604162 Replicon chromosome
Accession NZ_AP018782
Organism Haemophilus influenzae strain CHBN-V-2 isolate 13H37

Toxin (Protein)


Gene name VapD Uniprot ID A0A806DEN6
Locus tag K6J59_RS02970 Protein ID WP_005652099.1
Coordinates 604025..604162 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag K6J59_RS02965 Protein ID WP_005649350.1
Coordinates 603825..604016 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J59_RS08930 (CHBNV2_05510) 599702..599833 - 132 WP_260178610.1 hypothetical protein -
K6J59_RS02945 (CHBNV2_05520) 600033..601016 + 984 WP_005666498.1 DNA polymerase III subunit delta' -
K6J59_RS02950 (CHBNV2_05530) 601071..601853 + 783 WP_005649353.1 YchF/TatD family DNA exonuclease -
K6J59_RS02955 (CHBNV2_05540) 601880..602404 + 525 WP_005649352.1 DUF1523 family protein -
K6J59_RS02960 (CHBNV2_05550) 602455..603753 + 1299 WP_110434966.1 hemolysin family protein -
K6J59_RS02965 (CHBNV2_05560) 603825..604016 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
K6J59_RS02970 (CHBNV2_05570) 604025..604162 + 138 WP_005652099.1 hypothetical protein Toxin
K6J59_RS02975 (CHBNV2_05580) 604255..604785 + 531 WP_005649345.1 hypothetical protein -
K6J59_RS02980 (CHBNV2_05590) 604857..606356 + 1500 WP_005649342.1 fused PTS fructose transporter subunit IIA/HPr protein -
K6J59_RS02985 (CHBNV2_05600) 606358..607299 + 942 WP_005649339.1 1-phosphofructokinase -
K6J59_RS02990 (CHBNV2_05610) 607301..608971 + 1671 WP_005649337.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5256.88 Da        Isoelectric Point: 4.6701

>T32222 WP_005652099.1 NZ_AP018782:604025-604162 [Haemophilus influenzae]
MYAIAFDLVVKGTQDYHPKGVQQAYTDIGAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T32222 NZ_AP018782:604025-604162 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGGCACTCAAGATTATCATCCAAAGGGCGTTCAACAGGCTTATACAGA
CATTGGTGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT32222 WP_005649350.1 NZ_AP018782:603825-604016 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT32222 NZ_AP018782:603825-604016 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTATTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DEN6

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References