Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1702182..1702771 Replicon chromosome
Accession NZ_AP018781
Organism Haemophilus influenzae strain CHBN-V-1 isolate 13H43

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CHBNTHi_RS08535 Protein ID WP_110437755.1
Coordinates 1702523..1702771 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CHBNTHi_RS08530 Protein ID WP_110437754.1
Coordinates 1702182..1702526 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHBNTHi_RS08515 (CHBNV1_16280) 1697798..1700311 - 2514 WP_110437537.1 fimbria/pilus outer membrane usher protein -
CHBNTHi_RS08520 (CHBNV1_16290) 1700409..1701122 - 714 WP_005664618.1 fimbria/pilus periplasmic chaperone -
CHBNTHi_RS08525 (CHBNV1_16300) 1701435..1702085 + 651 WP_110437753.1 fimbrial protein -
CHBNTHi_RS08530 (CHBNV1_16310) 1702182..1702526 - 345 WP_110437754.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CHBNTHi_RS08535 (CHBNV1_16320) 1702523..1702771 - 249 WP_110437755.1 type II toxin-antitoxin system HicA family toxin Toxin
CHBNTHi_RS08540 (CHBNV1_16330) 1702942..1703436 + 495 WP_110437756.1 5-(carboxyamino)imidazole ribonucleotide mutase -
CHBNTHi_RS08545 (CHBNV1_16340) 1703506..1704594 + 1089 WP_110437757.1 5-(carboxyamino)imidazole ribonucleotide synthase -
CHBNTHi_RS08550 (CHBNV1_16350) 1704733..1705923 + 1191 WP_021035324.1 amino acid aminotransferase -
CHBNTHi_RS09895 1706008..1706136 - 129 Protein_1649 hydrogenase expression/formation protein HypE -
CHBNTHi_RS08555 (CHBNV1_16360) 1706146..1706763 - 618 WP_110437758.1 energy-coupling factor ABC transporter ATP-binding protein -
CHBNTHi_RS08560 (CHBNV1_16370) 1706765..1707397 - 633 WP_046949688.1 energy-coupling factor transporter transmembrane component T -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9424.99 Da        Isoelectric Point: 10.7140

>T32218 WP_110437755.1 NZ_AP018781:c1702771-1702523 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLKHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32218 NZ_AP018781:c1702771-1702523 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGTTCTCGAGTGAGATTTTATAATAGAACACTCAAGCATACGATTT
TGTTACACAAGCCTCATCCTGAAAATTATATTAAAGGCGGTGCTTTAAAATCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13092.96 Da        Isoelectric Point: 5.0042

>AT32218 WP_110437754.1 NZ_AP018781:c1702526-1702182 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFHQSVDLYLQDCLELGKEPNKPFKGVFNVRISEE
LHREATIIAGDRSLNAFVTEAIKEKISREKPSLR

Download         Length: 345 bp

>AT32218 NZ_AP018781:c1702526-1702182 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGTTAGAAAAAGAATTTCATCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTAGCGAGGAA
TTGCATAGAGAAGCAACAATCATAGCTGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCAATTAAAGAAAAAATTTC
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References