Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 775240..775877 Replicon chromosome
Accession NZ_AP018781
Organism Haemophilus influenzae strain CHBN-V-1 isolate 13H43

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag CHBNTHi_RS03930 Protein ID WP_005659980.1
Coordinates 775240..775644 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag CHBNTHi_RS03935 Protein ID WP_005656316.1
Coordinates 775641..775877 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHBNTHi_RS03900 (CHBNV1_07500) 770799..771365 + 567 WP_005669020.1 elongation factor P -
CHBNTHi_RS03910 (CHBNV1_07510) 771717..772304 - 588 WP_005654063.1 primosomal replication protein -
CHBNTHi_RS03915 (CHBNV1_07520) 772337..773689 - 1353 WP_005649062.1 Na+/H+ antiporter family protein -
CHBNTHi_RS03920 (CHBNV1_07530) 774003..774692 - 690 WP_005654067.1 ribonuclease T -
CHBNTHi_RS03925 (CHBNV1_07540) 774766..775173 - 408 WP_005654069.1 lactoylglutathione lyase -
CHBNTHi_RS03930 (CHBNV1_07550) 775240..775644 - 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
CHBNTHi_RS03935 (CHBNV1_07560) 775641..775877 - 237 WP_005656316.1 antitoxin Antitoxin
CHBNTHi_RS03940 (CHBNV1_07570) 775970..776695 - 726 WP_042611719.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
CHBNTHi_RS03945 (CHBNV1_07580) 776748..777266 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
CHBNTHi_RS03950 (CHBNV1_07590) 777485..779251 + 1767 WP_005669001.1 aspartate--tRNA ligase -
CHBNTHi_RS03955 (CHBNV1_07600) 779273..779746 + 474 WP_005666660.1 dihydroneopterin triphosphate diphosphatase -
CHBNTHi_RS03960 (CHBNV1_07610) 779758..780498 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T32215 WP_005659980.1 NZ_AP018781:c775644-775240 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T32215 NZ_AP018781:c775644-775240 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT32215 WP_005656316.1 NZ_AP018781:c775877-775641 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT32215 NZ_AP018781:c775877-775641 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References