Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 649246..649583 Replicon chromosome
Accession NZ_AP018781
Organism Haemophilus influenzae strain CHBN-V-1 isolate 13H43

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag CHBNTHi_RS03280 Protein ID WP_110437663.1
Coordinates 649446..649583 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag CHBNTHi_RS03275 Protein ID WP_005649350.1
Coordinates 649246..649437 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CHBNTHi_RS03255 (CHBNV1_06160) 645473..646453 + 981 WP_110437660.1 DNA polymerase III subunit delta' -
CHBNTHi_RS03260 (CHBNV1_06170) 646492..647274 + 783 WP_110437661.1 YchF/TatD family DNA exonuclease -
CHBNTHi_RS03265 (CHBNV1_06180) 647301..647825 + 525 WP_015701678.1 DUF1523 family protein -
CHBNTHi_RS03270 (CHBNV1_06190) 647876..649174 + 1299 WP_110437662.1 hemolysin family protein -
CHBNTHi_RS03275 (CHBNV1_06200) 649246..649437 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
CHBNTHi_RS03280 (CHBNV1_06210) 649446..649583 + 138 WP_110437663.1 virulence-associated protein D Toxin
CHBNTHi_RS03285 (CHBNV1_06220) 649676..650206 + 531 WP_005686915.1 hypothetical protein -
CHBNTHi_RS03290 (CHBNV1_06230) 650278..651777 + 1500 WP_110437664.1 fused PTS fructose transporter subunit IIA/HPr protein -
CHBNTHi_RS03295 (CHBNV1_06240) 651779..652720 + 942 WP_110437665.1 1-phosphofructokinase -
CHBNTHi_RS03300 (CHBNV1_06250) 652722..654392 + 1671 WP_110437666.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5271.89 Da        Isoelectric Point: 4.1133

>T32214 WP_110437663.1 NZ_AP018781:649446-649583 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAFLIEQWSDFTDFIRN

Download         Length: 138 bp

>T32214 NZ_AP018781:649446-649583 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAACAGGCTTATACAGA
CATTGGCGCTTTTCTTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT32214 WP_005649350.1 NZ_AP018781:649246-649437 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT32214 NZ_AP018781:649246-649437 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References