Detailed information of TA system TA032211

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 338733..339337
• Replicon: chromosome
• Accession: NZ_AP018781
• Organism: Haemophilus influenzae strain CHBN-V-1 isolate 13H43

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9S658
• Locus tag: CHBNTHi_RS01680
• Protein ID: WP_042593918.1
• Coordinates: 338733..339041 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4QMK8
• Locus tag: CHBNTHi_RS01685
• Protein ID: WP_005692346.1
• Coordinates: 339041..339337 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CHBNTHi_RS01670 (CHBNV1_03130)	333853..335151	-	1299	WP_015701821.1	trigger factor	-
CHBNTHi_RS09760	335455..335585	+	131	Protein_316	PT domain-containing protein	-
CHBNTHi_RS01675 (CHBNV1_03140)	335522..338674	+	3153	WP_221260930.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
CHBNTHi_RS01680 (CHBNV1_03150)	338733..339041	-	309	WP_042593918.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CHBNTHi_RS01685 (CHBNV1_03160)	339041..339337	-	297	WP_005692346.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CHBNTHi_RS01690 (CHBNV1_03170)	339457..340311	-	855	WP_110437474.1	DUF3298 domain-containing protein	-
CHBNTHi_RS01695 (CHBNV1_03180)	340330..342189	-	1860	WP_110437473.1	selenocysteine-specific translation elongation factor	-
CHBNTHi_RS01700 (CHBNV1_03190)	342186..343571	-	1386	WP_110437472.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-99)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11921.67 Da
• Isoelectric Point: 7.2393

>T32211 WP_042593918.1 NZ_AP018781:c339041-338733 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T32211 NZ_AP018781:c339041-338733 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11003.27 Da
• Isoelectric Point: 4.2845

>AT32211 WP_005692346.1 NZ_AP018781:c339337-339041 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT32211 NZ_AP018781:c339337-339041 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Toxin

• AlphaFold DB: Q9S658

Antitoxin

• AlphaFold DB: Q4QMK8