Detailed information of TA system TA032206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 349830..350301
• Replicon: chromosome
• Accession: NZ_AP018780
• Organism: Haemophilus influenzae strain CHBN-IV-1 isolate 13H36

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: K6J73_RS01725
• Protein ID: WP_005654546.1
• Coordinates: 349830..350012 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: K6J73_RS01730
• Protein ID: WP_005650837.1
• Coordinates: 350005..350301 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J73_RS09360	346542..346648	+	107	Protein_336	PT domain-containing protein	-
K6J73_RS09365	346626..346697	+	72	Protein_337	PT domain-containing protein	-
K6J73_RS01720 (CHBNIV1_03310)	346747..349560	+	2814	WP_246588239.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
K6J73_RS01725 (CHBNIV1_03320)	349830..350012	+	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
K6J73_RS01730 (CHBNIV1_03330)	350005..350301	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
K6J73_RS01735 (CHBNIV1_03340)	350485..352401	+	1917	WP_221253268.1	ABC transporter ATP-binding protein	-
K6J73_RS01740 (CHBNIV1_03350)	352411..352947	+	537	WP_221253269.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
K6J73_RS01745 (CHBNIV1_03360)	352963..353514	+	552	WP_075913443.1	Sua5/YciO/YrdC/YwlC family protein	-
K6J73_RS01750 (CHBNIV1_03370)	353518..354336	+	819	WP_221253270.1	shikimate dehydrogenase	-
K6J73_RS01755 (CHBNIV1_03380)	354333..354890	+	558	WP_075913439.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T32206 WP_005654546.1 NZ_AP018780:349830-350012 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T32206 NZ_AP018780:349830-350012 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTAAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACTGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT32206 WP_005650837.1 NZ_AP018780:350005-350301 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT32206 NZ_AP018780:350005-350301 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9