Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 74500..75034 Replicon chromosome
Accession NZ_AP018780
Organism Haemophilus influenzae strain CHBN-IV-1 isolate 13H36

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag K6J73_RS00375 Protein ID WP_005651512.1
Coordinates 74744..75034 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D0IHI1
Locus tag K6J73_RS00370 Protein ID WP_005663606.1
Coordinates 74500..74754 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J73_RS00335 (CHBNIV1_00670) 70086..70346 + 261 WP_005663579.1 hypothetical protein -
K6J73_RS00340 (CHBNIV1_00680) 70376..70741 + 366 WP_118873906.1 endonuclease domain-containing protein -
K6J73_RS00345 (CHBNIV1_00690) 71079..73145 + 2067 WP_221253158.1 glycine--tRNA ligase subunit beta -
K6J73_RS00355 (CHBNIV1_00710) 73663..73971 + 309 WP_112088251.1 P2 family phage major capsid protein -
K6J73_RS00365 (CHBNIV1_00720) 74203..74409 + 207 WP_005655873.1 hypothetical protein -
K6J73_RS00370 (CHBNIV1_00730) 74500..74754 + 255 WP_005663606.1 stability protein StbD Antitoxin
K6J73_RS00375 (CHBNIV1_00740) 74744..75034 + 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J73_RS00380 (CHBNIV1_00770) 75470..75607 + 138 WP_168770067.1 hypothetical protein -
K6J73_RS00385 (CHBNIV1_00780) 76002..77036 - 1035 WP_221253160.1 DNA polymerase III subunit delta -
K6J73_RS00390 (CHBNIV1_00790) 77036..77539 - 504 WP_112088252.1 LPS assembly lipoprotein LptE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T32204 WP_005651512.1 NZ_AP018780:74744-75034 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T32204 NZ_AP018780:74744-75034 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACCATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9433.81 Da        Isoelectric Point: 4.0737

>AT32204 WP_005663606.1 NZ_AP018780:74500-74754 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPIEVD
LNDL

Download         Length: 255 bp

>AT32204 NZ_AP018780:74500-74754 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCAGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAACTCGGCAGAATGGCAAATGAACGGCTTGCCACTCTTGAACCTATAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A0D0IHI1

References