Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1526175..1526764 Replicon chromosome
Accession NZ_AP018779
Organism Haemophilus influenzae strain CHBN-III-8 isolate 10H15

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J62_RS07465 Protein ID WP_005653200.1
Coordinates 1526516..1526764 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9R3J9
Locus tag K6J62_RS07460 Protein ID WP_005668366.1
Coordinates 1526175..1526519 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J62_RS07445 (CHBNIII8_14180) 1521689..1524202 - 2514 WP_040034811.1 fimbria/pilus outer membrane usher protein -
K6J62_RS07450 (CHBNIII8_14190) 1524339..1525052 - 714 WP_110431680.1 fimbria/pilus periplasmic chaperone -
K6J62_RS07455 (CHBNIII8_14200) 1525434..1526078 + 645 WP_110431551.1 fimbrial protein -
K6J62_RS07460 (CHBNIII8_14210) 1526175..1526519 - 345 WP_005668366.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J62_RS07465 (CHBNIII8_14220) 1526516..1526764 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J62_RS07470 (CHBNIII8_14230) 1526935..1527429 + 495 WP_005664624.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J62_RS07475 (CHBNIII8_14240) 1527499..1528587 + 1089 WP_110431552.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J62_RS07480 (CHBNIII8_14250) 1528727..1529917 + 1191 WP_005657030.1 amino acid aminotransferase -
K6J62_RS07485 (CHBNIII8_14260) 1530024..1530650 - 627 WP_005686589.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J62_RS07490 (CHBNIII8_14270) 1530652..1531284 - 633 WP_110431553.1 energy-coupling factor transporter transmembrane component T -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32202 WP_005653200.1 NZ_AP018779:c1526764-1526516 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32202 NZ_AP018779:c1526764-1526516 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.08 Da        Isoelectric Point: 5.0113

>AT32202 WP_005668366.1 NZ_AP018779:c1526519-1526175 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Download         Length: 345 bp

>AT32202 NZ_AP018779:c1526519-1526175 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATAATAGCTGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCGATTAAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A806E3Y3

References