Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46377..47008 Replicon chromosome
Accession NZ_AP018779
Organism Haemophilus influenzae strain CHBN-III-8 isolate 10H15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K6J62_RS00225 Protein ID WP_110431771.1
Coordinates 46610..47008 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K6J62_RS00220 Protein ID WP_110431772.1
Coordinates 46377..46610 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J62_RS00195 (CHBNIII8_00390) 41855..43057 - 1203 WP_110431774.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
K6J62_RS00200 (CHBNIII8_00400) 43221..43886 + 666 WP_032821549.1 DNA repair protein RadC -
K6J62_RS00205 (CHBNIII8_00410) 44100..44336 + 237 WP_005542826.1 50S ribosomal protein L28 -
K6J62_RS00210 (CHBNIII8_00420) 44348..44518 + 171 WP_005613503.1 50S ribosomal protein L33 -
K6J62_RS00215 (CHBNIII8_00430) 44866..46230 + 1365 WP_110431773.1 diaminobutyrate--2-oxoglutarate transaminase -
K6J62_RS00220 (CHBNIII8_00440) 46377..46610 + 234 WP_110431772.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
K6J62_RS00225 (CHBNIII8_00450) 46610..47008 + 399 WP_110431771.1 tRNA(fMet)-specific endonuclease VapC Toxin
K6J62_RS00230 (CHBNIII8_00460) 47028..48563 + 1536 WP_110426321.1 L-2,4-diaminobutyrate decarboxylase -
K6J62_RS00235 (CHBNIII8_00470) 48794..49609 + 816 WP_005655938.1 DNA-formamidopyrimidine glycosylase -
K6J62_RS00240 (CHBNIII8_00480) 49683..50705 - 1023 WP_038440108.1 outer membrane-stress sensor serine endopeptidase DegS -
K6J62_RS00245 (CHBNIII8_00490) 50706..51824 - 1119 WP_110431770.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15143.51 Da        Isoelectric Point: 8.0514

>T32197 WP_110431771.1 NZ_AP018779:46610-47008 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIVAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T32197 NZ_AP018779:46610-47008 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCTGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGTGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8939.02 Da        Isoelectric Point: 4.3094

>AT32197 WP_110431772.1 NZ_AP018779:46377-46610 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQEVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT32197 NZ_AP018779:46377-46610 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGAAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References