Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 991829..992476 | Replicon | chromosome |
| Accession | NZ_AP018778 | ||
| Organism | Haemophilus influenzae strain CHBN-III-7 isolate 15H01 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | K6J60_RS05080 | Protein ID | WP_005642982.1 |
| Coordinates | 991829..992047 (+) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A806ED58 |
| Locus tag | K6J60_RS05085 | Protein ID | WP_005642973.1 |
| Coordinates | 992075..992476 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J60_RS05040 (CHBNIII7_09430) | 987021..987212 | + | 192 | WP_221267186.1 | hypothetical protein | - |
| K6J60_RS05045 (CHBNIII7_09440) | 987224..987505 | + | 282 | WP_015967401.1 | hypothetical protein | - |
| K6J60_RS05050 (CHBNIII7_09450) | 987556..987816 | + | 261 | WP_221267187.1 | hypothetical protein | - |
| K6J60_RS05055 (CHBNIII7_09460) | 987819..990146 | + | 2328 | WP_221267188.1 | replication endonuclease | - |
| K6J60_RS05060 (CHBNIII7_09470) | 990158..990457 | + | 300 | WP_221267189.1 | hypothetical protein | - |
| K6J60_RS05065 (CHBNIII7_09480) | 990471..990680 | + | 210 | WP_015979415.1 | hypothetical protein | - |
| K6J60_RS05070 (CHBNIII7_09490) | 990693..991244 | + | 552 | WP_118805097.1 | MazG-like family protein | - |
| K6J60_RS05075 (CHBNIII7_09500) | 991255..991773 | + | 519 | WP_221267520.1 | phage N-6-adenine-methyltransferase | - |
| K6J60_RS05080 (CHBNIII7_09510) | 991829..992047 | + | 219 | WP_005642982.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K6J60_RS05085 (CHBNIII7_09520) | 992075..992476 | + | 402 | WP_005642973.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K6J60_RS05090 (CHBNIII7_09530) | 992503..992763 | - | 261 | WP_221267190.1 | ogr/Delta-like zinc finger family protein | - |
| K6J60_RS05095 (CHBNIII7_09540) | 992844..993881 | - | 1038 | WP_118805315.1 | phage portal protein | - |
| K6J60_RS05100 (CHBNIII7_09550) | 993871..995694 | - | 1824 | WP_112080718.1 | terminase ATPase subunit family protein | - |
| K6J60_RS05105 | 995683..995910 | + | 228 | WP_112122672.1 | hypothetical protein | - |
| K6J60_RS05110 (CHBNIII7_09560) | 995913..996806 | + | 894 | WP_112122671.1 | GPO family capsid scaffolding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 983120..1014422 | 31302 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8160.35 Da Isoelectric Point: 9.9306
>T32195 WP_005642982.1 NZ_AP018778:991829-992047 [Haemophilus influenzae]
VGIITTIERQEGETVDSKTAIKMIEEDGWYLDRVKGSHHQYKHPTKKGTVTIPHPRKDLGHLEKSIKKQAGL
VGIITTIERQEGETVDSKTAIKMIEEDGWYLDRVKGSHHQYKHPTKKGTVTIPHPRKDLGHLEKSIKKQAGL
Download Length: 219 bp
>T32195 NZ_AP018778:991829-992047 [Haemophilus influenzae]
GTGGGTATAATAACCACCATTGAAAGGCAAGAGGGAGAAACAGTGGATAGCAAAACAGCAATAAAAATGATAGAAGAGGA
CGGTTGGTATTTAGATAGAGTTAAAGGTAGTCATCATCAATACAAACATCCTACAAAAAAGGGAACGGTCACGATTCCCC
ACCCAAGGAAAGACTTGGGGCATTTAGAAAAAAGCATTAAAAAACAAGCGGGGCTGTAA
GTGGGTATAATAACCACCATTGAAAGGCAAGAGGGAGAAACAGTGGATAGCAAAACAGCAATAAAAATGATAGAAGAGGA
CGGTTGGTATTTAGATAGAGTTAAAGGTAGTCATCATCAATACAAACATCCTACAAAAAAGGGAACGGTCACGATTCCCC
ACCCAAGGAAAGACTTGGGGCATTTAGAAAAAAGCATTAAAAAACAAGCGGGGCTGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14922.06 Da Isoelectric Point: 4.3937
>AT32195 WP_005642973.1 NZ_AP018778:992075-992476 [Haemophilus influenzae]
MLYPICIEKVNDGYVVSVPDVPGCFSAGDTLSEAMLNAKEAISFHIEGMLEDDEELPKSNPIEQYINQPEYKDFIVTVVD
VDLTHLMGKAEKINITVPALLLHRIDQFIATHPEYKNRSNFLSQLATNRLLSA
MLYPICIEKVNDGYVVSVPDVPGCFSAGDTLSEAMLNAKEAISFHIEGMLEDDEELPKSNPIEQYINQPEYKDFIVTVVD
VDLTHLMGKAEKINITVPALLLHRIDQFIATHPEYKNRSNFLSQLATNRLLSA
Download Length: 402 bp
>AT32195 NZ_AP018778:992075-992476 [Haemophilus influenzae]
ATGTTATACCCAATTTGTATCGAAAAAGTAAATGATGGTTATGTGGTATCTGTGCCAGATGTGCCAGGCTGTTTTTCTGC
TGGGGATACCTTATCAGAAGCAATGTTAAACGCAAAAGAAGCAATCTCTTTTCACATTGAAGGGATGTTAGAAGATGATG
AAGAATTGCCTAAATCTAACCCAATAGAACAATATATTAATCAGCCCGAATATAAAGATTTTATTGTCACTGTTGTTGAT
GTAGATTTAACTCATTTAATGGGTAAGGCGGAAAAAATTAATATTACGGTTCCAGCGTTATTACTGCACCGCATTGATCA
GTTTATTGCCACTCATCCAGAATATAAGAATAGAAGTAACTTTTTGTCTCAACTAGCAACAAATAGATTACTTTCTGCAT
AA
ATGTTATACCCAATTTGTATCGAAAAAGTAAATGATGGTTATGTGGTATCTGTGCCAGATGTGCCAGGCTGTTTTTCTGC
TGGGGATACCTTATCAGAAGCAATGTTAAACGCAAAAGAAGCAATCTCTTTTCACATTGAAGGGATGTTAGAAGATGATG
AAGAATTGCCTAAATCTAACCCAATAGAACAATATATTAATCAGCCCGAATATAAAGATTTTATTGTCACTGTTGTTGAT
GTAGATTTAACTCATTTAATGGGTAAGGCGGAAAAAATTAATATTACGGTTCCAGCGTTATTACTGCACCGCATTGATCA
GTTTATTGCCACTCATCCAGAATATAAGAATAGAAGTAACTTTTTGTCTCAACTAGCAACAAATAGATTACTTTCTGCAT
AA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|