32194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 602449..602927 Replicon chromosome
Accession NZ_AP018778
Organism Haemophilus influenzae strain CHBN-III-7 isolate 15H01

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag K6J60_RS03080 Protein ID WP_005656500.1
Coordinates 602649..602927 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag K6J60_RS03075 Protein ID WP_005649350.1
Coordinates 602449..602640 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J60_RS03050 (CHBNIII7_05750) 598028..598660 + 633 WP_221267515.1 dTMP kinase -
K6J60_RS03055 (CHBNIII7_05760) 598657..599640 + 984 WP_221267514.1 DNA polymerase III subunit delta' -
K6J60_RS03060 (CHBNIII7_05770) 599695..600477 + 783 WP_221267418.1 YchF/TatD family DNA exonuclease -
K6J60_RS03065 (CHBNIII7_05780) 600504..601028 + 525 WP_221267419.1 DUF1523 family protein -
K6J60_RS03070 (CHBNIII7_05790) 601079..602377 + 1299 WP_221267420.1 hemolysin family protein -
K6J60_RS03075 (CHBNIII7_05800) 602449..602640 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
K6J60_RS03080 (CHBNIII7_05810) 602649..602927 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
K6J60_RS03085 (CHBNIII7_05820) 603020..603550 + 531 WP_221253376.1 hypothetical protein -
K6J60_RS03090 (CHBNIII7_05830) 603622..605121 + 1500 WP_221267421.1 fused PTS fructose transporter subunit IIA/HPr protein -
K6J60_RS03095 (CHBNIII7_05840) 605123..606064 + 942 WP_221267422.1 1-phosphofructokinase -
K6J60_RS03100 (CHBNIII7_05850) 606066..607736 + 1671 WP_118807513.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T32194 WP_005656500.1 NZ_AP018778:602649-602927 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T32194 NZ_AP018778:602649-602927 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCTGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT32194 WP_005649350.1 NZ_AP018778:602449-602640 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT32194 NZ_AP018778:602449-602640 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References