Detailed information of TA system TA032193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 338017..338488
• Replicon: chromosome
• Accession: NZ_AP018778
• Organism: Haemophilus influenzae strain CHBN-III-7 isolate 15H01

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: K6J60_RS01680
• Protein ID: WP_005654546.1
• Coordinates: 338017..338199 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: K6J60_RS01685
• Protein ID: WP_221267377.1
• Coordinates: 338192..338488 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J60_RS01675 (CHBNIII7_03220)	334706..337756	+	3051	WP_221267376.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
K6J60_RS01680 (CHBNIII7_03230)	338017..338199	+	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
K6J60_RS01685 (CHBNIII7_03240)	338192..338488	+	297	WP_221267377.1	helix-turn-helix transcriptional regulator	Antitoxin
K6J60_RS01690 (CHBNIII7_03250)	338672..340588	+	1917	WP_221267378.1	ABC transporter ATP-binding protein	-
K6J60_RS01695 (CHBNIII7_03260)	340598..341134	+	537	WP_105895785.1	type I DNA topoisomerase	-
K6J60_RS01700 (CHBNIII7_03270)	341150..341701	+	552	WP_221267379.1	Sua5/YciO/YrdC/YwlC family protein	-
K6J60_RS01705 (CHBNIII7_03280)	341705..342523	+	819	WP_221267380.1	shikimate dehydrogenase	-
K6J60_RS01710 (CHBNIII7_03290)	342520..343077	+	558	WP_040034200.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T32193 WP_005654546.1 NZ_AP018778:338017-338199 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T32193 NZ_AP018778:338017-338199 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11082.90 Da
• Isoelectric Point: 10.3139

>AT32193 WP_221267377.1 NZ_AP018778:338192-338488 [Haemophilus influenzae]
MNKISSLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT32193 NZ_AP018778:338192-338488 [Haemophilus influenzae]
ATGAATAAAATCAGCTCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9