Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 294486..295090 Replicon chromosome
Accession NZ_AP018778
Organism Haemophilus influenzae strain CHBN-III-7 isolate 15H01

Toxin (Protein)


Gene name relE Uniprot ID A0A2S9RBL9
Locus tag K6J60_RS01465 Protein ID WP_050948779.1
Coordinates 294486..294794 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Y7JSS2
Locus tag K6J60_RS01470 Protein ID WP_005661259.1
Coordinates 294794..295090 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J60_RS01455 (CHBNIII7_02790) 289523..290821 - 1299 WP_015701821.1 trigger factor -
K6J60_RS01460 (CHBNIII7_02800) 291125..294427 + 3303 WP_221267363.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
K6J60_RS01465 (CHBNIII7_02810) 294486..294794 - 309 WP_050948779.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J60_RS01470 (CHBNIII7_02820) 294794..295090 - 297 WP_005661259.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J60_RS01475 (CHBNIII7_02830) 295209..296063 - 855 WP_221267364.1 DUF3298 domain-containing protein -
K6J60_RS01480 (CHBNIII7_02840) 296082..297941 - 1860 WP_221267365.1 selenocysteine-specific translation elongation factor -
K6J60_RS01485 (CHBNIII7_02850) 297938..299323 - 1386 WP_221267366.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11949.72 Da        Isoelectric Point: 7.8657

>T32191 WP_050948779.1 NZ_AP018778:c294794-294486 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T32191 NZ_AP018778:c294794-294486 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.37 Da        Isoelectric Point: 4.4297

>AT32191 WP_005661259.1 NZ_AP018778:c295090-294794 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT32191 NZ_AP018778:c295090-294794 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGTTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9RBL9

Antitoxin

Source ID Structure
AlphaFold DB A0A0Y7JSS2

References