Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1375095..1375720 Replicon chromosome
Accession NZ_AP018777
Organism Haemophilus influenzae strain CHBN-III-6 isolate 13H31

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K6J69_RS06895 Protein ID WP_110431015.1
Coordinates 1375095..1375277 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K6J69_RS06900 Protein ID WP_105881575.1
Coordinates 1375307..1375720 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J69_RS06855 (CHBNIII6_13090) 1370690..1371448 + 759 WP_110431011.1 helix-turn-helix domain-containing protein -
K6J69_RS06860 (CHBNIII6_13100) 1371433..1372068 + 636 WP_110431012.1 replication protein P -
K6J69_RS06865 (CHBNIII6_13110) 1372065..1372289 + 225 WP_005633909.1 hypothetical protein -
K6J69_RS06870 1372326..1372740 + 415 Protein_1310 recombination protein NinB -
K6J69_RS06875 (CHBNIII6_13140) 1372829..1373371 + 543 WP_110431013.1 recombination protein NinG -
K6J69_RS06880 (CHBNIII6_13150) 1373368..1373739 + 372 WP_105896031.1 antiterminator Q family protein -
K6J69_RS06885 (CHBNIII6_13160) 1374059..1374553 - 495 WP_105896032.1 hypothetical protein -
K6J69_RS06890 (CHBNIII6_13170) 1374565..1374912 - 348 WP_105896033.1 helix-turn-helix transcriptional regulator -
K6J69_RS06895 (CHBNIII6_13180) 1375095..1375277 + 183 WP_110431015.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J69_RS06900 (CHBNIII6_13190) 1375307..1375720 + 414 WP_105881575.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J69_RS06905 (CHBNIII6_13200) 1376025..1376699 + 675 WP_110431016.1 BRO family protein -
K6J69_RS06910 (CHBNIII6_13210) 1376795..1378837 + 2043 WP_192876602.1 ATP-dependent Clp protease proteolytic subunit -
K6J69_RS06915 (CHBNIII6_13220) 1378916..1379239 + 324 WP_005651203.1 DUF2190 family protein -
K6J69_RS06920 (CHBNIII6_13230) 1379220..1379531 + 312 WP_005651204.1 hypothetical protein -
K6J69_RS06925 (CHBNIII6_13240) 1379534..1380064 + 531 WP_110431017.1 phage tail protein -
K6J69_RS06930 (CHBNIII6_13250) 1380112..1380483 + 372 WP_230304754.1 phage minor tail U family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1355992..1399184 43192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6817.92 Da        Isoelectric Point: 10.4324

>T32187 WP_110431015.1 NZ_AP018777:1375095-1375277 [Haemophilus influenzae]
VDSQKIIKMIETDGWVFHHATESHHHFTHPIKKGIVTVPHPKKDLKKGTENSILKQAGLK

Download         Length: 183 bp

>T32187 NZ_AP018777:1375095-1375277 [Haemophilus influenzae]
GTGGATAGTCAAAAAATAATTAAGATGATTGAAACGGATGGTTGGGTTTTCCATCACGCCACAGAAAGCCACCATCACTT
CACGCATCCAATAAAGAAAGGGATTGTTACCGTCCCACATCCTAAAAAGGATTTAAAGAAAGGGACGGAAAATTCAATAT
TAAAACAAGCGGGGCTAAAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15185.32 Da        Isoelectric Point: 4.4483

>AT32187 WP_105881575.1 NZ_AP018777:1375307-1375720 [Haemophilus influenzae]
MLYPIAIEPGDETHAFGVIVPDIPGCFSAGDTLEEAYINAKEAIAGHLELLVEMGEEVPLPTSMENHRNNPDFTDYGMFF
GVVDVDITHLLGKSEKINITMPAYLIKRIDDFVSTHREYKNRSSFLAKIAADKILSA

Download         Length: 414 bp

>AT32187 NZ_AP018777:1375307-1375720 [Haemophilus influenzae]
ATGTTATATCCAATCGCAATTGAGCCAGGCGACGAAACTCACGCATTTGGTGTGATTGTGCCAGATATTCCTGGCTGTTT
TTCTGCCGGTGATACGCTTGAAGAAGCTTATATTAATGCGAAAGAAGCTATTGCGGGGCATTTGGAATTATTGGTTGAAA
TGGGCGAAGAAGTGCCATTGCCAACATCAATGGAAAATCACCGTAACAACCCTGATTTTACTGATTATGGCATGTTCTTT
GGTGTGGTGGATGTGGATATTACCCATTTATTGGGTAAATCTGAGAAAATCAACATCACAATGCCGGCTTATTTAATTAA
GCGCATTGATGATTTTGTTTCAACACATCGTGAATATAAAAACCGTAGCAGTTTTTTAGCTAAAATCGCAGCAGATAAGA
TCTTATCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References