Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 779931..780568 Replicon chromosome
Accession NZ_AP018777
Organism Haemophilus influenzae strain CHBN-III-6 isolate 13H31

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0D0IEZ6
Locus tag K6J69_RS03895 Protein ID WP_005662950.1
Coordinates 780164..780568 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag K6J69_RS03890 Protein ID WP_005656316.1
Coordinates 779931..780167 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J69_RS03865 (CHBNIII6_07370) 775308..776048 - 741 WP_005662961.1 YebC/PmpR family DNA-binding transcriptional regulator -
K6J69_RS03870 (CHBNIII6_07380) 776061..776534 - 474 WP_162632253.1 dihydroneopterin triphosphate diphosphatase -
K6J69_RS03875 (CHBNIII6_07390) 776556..778322 - 1767 WP_110431159.1 aspartate--tRNA ligase -
K6J69_RS03880 (CHBNIII6_07400) 778541..779059 + 519 WP_005688985.1 isoprenylcysteine carboxyl methyltransferase family protein -
K6J69_RS03885 (CHBNIII6_07410) 779113..779838 + 726 WP_005662952.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
K6J69_RS03890 (CHBNIII6_07420) 779931..780167 + 237 WP_005656316.1 antitoxin Antitoxin
K6J69_RS03895 (CHBNIII6_07430) 780164..780568 + 405 WP_005662950.1 type II toxin-antitoxin system VapC family toxin Toxin
K6J69_RS03900 (CHBNIII6_07440) 780635..781042 + 408 WP_005628548.1 lactoylglutathione lyase -
K6J69_RS03905 (CHBNIII6_07450) 781116..781805 + 690 WP_005686760.1 ribonuclease T -
K6J69_RS03910 (CHBNIII6_07460) 782119..783471 + 1353 WP_110431158.1 Na+/H+ antiporter family protein -
K6J69_RS03915 (CHBNIII6_07470) 783503..784087 + 585 WP_110431157.1 primosomal replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15641.18 Da        Isoelectric Point: 8.4694

>T32186 WP_005662950.1 NZ_AP018777:780164-780568 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGQPIGNNDLWIACHALSLNAVLITHNVKEFHRITDLQWQDWTK

Download         Length: 405 bp

>T32186 NZ_AP018777:780164-780568 [Haemophilus influenzae]
ATGATTTATATGTTAGACACTAATATCATTATTTATTTAATGAAAAATCGTCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCGTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTGCTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCAACCTATCGGAAATAATGACCTATGGATTGCTTGCCACGCTTT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAGTTTCATCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT32186 WP_005656316.1 NZ_AP018777:779931-780167 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT32186 NZ_AP018777:779931-780167 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGAGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D0IEZ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References