Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 248108..248712 Replicon chromosome
Accession NZ_AP018777
Organism Haemophilus influenzae strain CHBN-III-6 isolate 13H31

Toxin (Protein)


Gene name relE Uniprot ID A0A822VCP0
Locus tag K6J69_RS01285 Protein ID WP_015701819.1
Coordinates 248404..248712 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag K6J69_RS01280 Protein ID WP_005692346.1
Coordinates 248108..248404 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J69_RS01265 (CHBNIII6_02480) 243874..245259 + 1386 WP_110430686.1 L-seryl-tRNA(Sec) selenium transferase -
K6J69_RS01270 (CHBNIII6_02490) 245256..247115 + 1860 WP_110430687.1 selenocysteine-specific translation elongation factor -
K6J69_RS01275 (CHBNIII6_02500) 247134..247988 + 855 WP_042601720.1 DUF3298 domain-containing protein -
K6J69_RS01280 (CHBNIII6_02510) 248108..248404 + 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J69_RS01285 (CHBNIII6_02520) 248404..248712 + 309 WP_015701819.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J69_RS01290 (CHBNIII6_02530) 248769..251021 - 2253 WP_260178089.1 TonB-dependent receptor -
K6J69_RS09355 251448..251846 - 399 Protein_255 TonB-dependent receptor plug domain-containing protein -
K6J69_RS09360 (CHBNIII6_02540) 251780..251962 - 183 WP_232500782.1 PT domain-containing protein -
K6J69_RS01295 (CHBNIII6_02550) 252379..252618 + 240 WP_005651317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hgpC / hgpC 242375..252618 10243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11919.74 Da        Isoelectric Point: 8.9408

>T32185 WP_015701819.1 NZ_AP018777:248404-248712 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IQDKFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T32185 NZ_AP018777:248404-248712 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACAGGATAAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT32185 WP_005692346.1 NZ_AP018777:248108-248404 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT32185 NZ_AP018777:248108-248404 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822VCP0

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References