Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 563307..563635 Replicon chromosome
Accession NZ_AP018776
Organism Haemophilus influenzae strain CHBN-III-5 isolate 13H30

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag K6J67_RS02835 Protein ID WP_005686917.1
Coordinates 563498..563635 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID -
Locus tag K6J67_RS02830 Protein ID WP_050822814.1
Coordinates 563307..563489 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J67_RS02805 (CHBNIII5_05380) 558886..559518 + 633 WP_005686927.1 dTMP kinase -
K6J67_RS02810 (CHBNIII5_05390) 559515..560498 + 984 WP_014550403.1 DNA polymerase III subunit delta' -
K6J67_RS02815 (CHBNIII5_05400) 560553..561335 + 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
K6J67_RS02820 (CHBNIII5_05410) 561362..561886 + 525 WP_005686921.1 DUF1523 family protein -
K6J67_RS02825 (CHBNIII5_05420) 561937..563235 + 1299 WP_014550404.1 hemolysin family protein -
K6J67_RS02830 (CHBNIII5_05430) 563307..563489 + 183 WP_050822814.1 DUF5397 family protein Antitoxin
K6J67_RS02835 (CHBNIII5_05440) 563498..563635 + 138 WP_005686917.1 hypothetical protein Toxin
K6J67_RS02840 (CHBNIII5_05450) 563728..564258 + 531 WP_005686915.1 hypothetical protein -
K6J67_RS02845 (CHBNIII5_05460) 564330..565829 + 1500 WP_050822813.1 fused PTS fructose transporter subunit IIA/HPr protein -
K6J67_RS02850 (CHBNIII5_05470) 565831..566772 + 942 WP_014550407.1 1-phosphofructokinase -
K6J67_RS02855 (CHBNIII5_05480) 566774..568444 + 1671 WP_050822812.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-60)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T32181 WP_005686917.1 NZ_AP018776:563498-563635 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T32181 NZ_AP018776:563498-563635 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6730.71 Da        Isoelectric Point: 3.9930

>AT32181 WP_050822814.1 NZ_AP018776:563307-563489 [Haemophilus influenzae]
MELRQQIPTGCIKQFGVPYVVGEVAEFLLDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 183 bp

>AT32181 NZ_AP018776:563307-563489 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGTTGCGGAATT
TTTGCTAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTATCTCACCTAC
TTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure

References