Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 305747..306351 Replicon chromosome
Accession NZ_AP018776
Organism Haemophilus influenzae strain CHBN-III-5 isolate 13H30

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K6J67_RS01535 Protein ID WP_050823020.1
Coordinates 305747..306055 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K6J67_RS01540 Protein ID WP_005664792.1
Coordinates 306055..306351 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J67_RS01520 (CHBNIII5_02940) 300866..302164 - 1299 WP_050823045.1 trigger factor -
K6J67_RS08920 302494..302586 + 93 Protein_297 PT domain-containing protein -
K6J67_RS01530 (CHBNIII5_02960) 302736..305690 + 2955 WP_246588186.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
K6J67_RS01535 (CHBNIII5_02970) 305747..306055 - 309 WP_050823020.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J67_RS01540 (CHBNIII5_02980) 306055..306351 - 297 WP_005664792.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J67_RS01545 (CHBNIII5_02990) 306471..307325 - 855 WP_050823021.1 DUF3298 domain-containing protein -
K6J67_RS01550 (CHBNIII5_03000) 307344..309203 - 1860 WP_050823022.1 selenocysteine-specific translation elongation factor -
K6J67_RS01555 (CHBNIII5_03010) 309200..310585 - 1386 WP_014551098.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11962.77 Da        Isoelectric Point: 8.4515

>T32178 WP_050823020.1 NZ_AP018776:c306055-305747 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNLLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T32178 NZ_AP018776:c306055-305747 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATTTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11061.31 Da        Isoelectric Point: 4.2087

>AT32178 WP_005664792.1 NZ_AP018776:c306351-306055 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLEAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT32178 NZ_AP018776:c306351-306055 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGAAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References