Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 75313..75847 Replicon chromosome
Accession NZ_AP018776
Organism Haemophilus influenzae strain CHBN-III-5 isolate 13H30

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag K6J67_RS00375 Protein ID WP_005651512.1
Coordinates 75557..75847 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag K6J67_RS00370 Protein ID WP_005651514.1
Coordinates 75313..75567 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J67_RS00335 (CHBNIII5_00690) 70493..70753 + 261 WP_005663579.1 hypothetical protein -
K6J67_RS00340 (CHBNIII5_00700) 70783..71148 + 366 WP_005686191.1 endonuclease domain-containing protein -
K6J67_RS00345 (CHBNIII5_00710) 71486..73552 + 2067 WP_005686190.1 glycine--tRNA ligase subunit beta -
K6J67_RS00355 (CHBNIII5_00720) 73914..74453 + 540 WP_005659144.1 hypothetical protein -
K6J67_RS00360 (CHBNIII5_00730) 74483..74791 + 309 WP_005659142.1 P2 family phage major capsid protein -
K6J67_RS00365 (CHBNIII5_00740) 74791..75015 + 225 WP_005659141.1 hypothetical protein -
K6J67_RS00370 (CHBNIII5_00750) 75313..75567 + 255 WP_005651514.1 stability protein StbD Antitoxin
K6J67_RS00375 (CHBNIII5_00760) 75557..75847 + 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J67_RS00380 (CHBNIII5_00770) 75883..76137 + 255 WP_014551014.1 hypothetical protein -
K6J67_RS00385 (CHBNIII5_00790) 76307..76444 + 138 WP_005659136.1 hypothetical protein -
K6J67_RS00390 (CHBNIII5_00800) 76965..77999 - 1035 WP_005659128.1 DNA polymerase III subunit delta -
K6J67_RS00395 (CHBNIII5_00810) 77999..78502 - 504 WP_005659127.1 LPS assembly lipoprotein LptE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T32177 WP_005651512.1 NZ_AP018776:75557-75847 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T32177 NZ_AP018776:75557-75847 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT32177 WP_005651514.1 NZ_AP018776:75313-75567 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT32177 NZ_AP018776:75313-75567 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References