Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1578022..1578611 Replicon chromosome
Accession NZ_AP018775
Organism Haemophilus influenzae strain CHBN-III-4 isolate 12H35

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J64_RS07750 Protein ID WP_005653200.1
Coordinates 1578363..1578611 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag K6J64_RS07745 Protein ID WP_005653201.1
Coordinates 1578022..1578366 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J64_RS07730 (CHBNIII4_14670) 1573245..1574639 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
K6J64_RS07735 (CHBNIII4_14680) 1574683..1575297 + 615 WP_042602710.1 riboflavin synthase -
K6J64_RS07740 (CHBNIII4_14690) 1575369..1577978 - 2610 WP_048946816.1 aminopeptidase N -
K6J64_RS07745 (CHBNIII4_14700) 1578022..1578366 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J64_RS07750 (CHBNIII4_14710) 1578363..1578611 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J64_RS07755 (CHBNIII4_14720) 1578782..1579276 + 495 WP_042593849.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J64_RS07760 (CHBNIII4_14730) 1579346..1580434 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J64_RS07765 (CHBNIII4_14740) 1580574..1581764 + 1191 WP_005657030.1 amino acid aminotransferase -
K6J64_RS07770 (CHBNIII4_14750) 1581871..1582497 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J64_RS07775 (CHBNIII4_14760) 1582499..1583131 - 633 WP_042593846.1 energy-coupling factor transporter transmembrane component T -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32175 WP_005653200.1 NZ_AP018775:c1578611-1578363 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32175 NZ_AP018775:c1578611-1578363 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT32175 WP_005653201.1 NZ_AP018775:c1578366-1578022 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT32175 NZ_AP018775:c1578366-1578022 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References