Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 682590..683227 Replicon chromosome
Accession NZ_AP018775
Organism Haemophilus influenzae strain CHBN-III-4 isolate 12H35

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag K6J64_RS03475 Protein ID WP_005659980.1
Coordinates 682590..682994 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag K6J64_RS03480 Protein ID WP_005656316.1
Coordinates 682991..683227 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J64_RS03445 (CHBNIII4_06610) 678148..678714 + 567 WP_005544066.1 elongation factor P -
K6J64_RS03455 (CHBNIII4_06620) 679066..679653 - 588 WP_014550467.1 primosomal replication protein -
K6J64_RS03460 (CHBNIII4_06630) 679686..681038 - 1353 WP_014550468.1 Na+/H+ antiporter family protein -
K6J64_RS03465 (CHBNIII4_06640) 681353..682042 - 690 WP_005659978.1 ribonuclease T -
K6J64_RS03470 (CHBNIII4_06650) 682116..682523 - 408 WP_014550469.1 lactoylglutathione lyase -
K6J64_RS03475 (CHBNIII4_06660) 682590..682994 - 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
K6J64_RS03480 (CHBNIII4_06670) 682991..683227 - 237 WP_005656316.1 antitoxin Antitoxin
K6J64_RS03485 (CHBNIII4_06680) 683320..684045 - 726 WP_014550471.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
K6J64_RS03490 (CHBNIII4_06690) 684098..684616 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
K6J64_RS03495 (CHBNIII4_06700) 684835..686601 + 1767 WP_014550472.1 aspartate--tRNA ligase -
K6J64_RS03500 (CHBNIII4_06710) 686623..687099 + 477 WP_005686755.1 dihydroneopterin triphosphate diphosphatase -
K6J64_RS03505 (CHBNIII4_06720) 687259..687999 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T32173 WP_005659980.1 NZ_AP018775:c682994-682590 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T32173 NZ_AP018775:c682994-682590 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT32173 WP_005656316.1 NZ_AP018775:c683227-682991 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT32173 NZ_AP018775:c683227-682991 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAAGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References