Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 557712..558049 Replicon chromosome
Accession NZ_AP018775
Organism Haemophilus influenzae strain CHBN-III-4 isolate 12H35

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag K6J64_RS02825 Protein ID WP_005686917.1
Coordinates 557912..558049 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag K6J64_RS02820 Protein ID WP_005649350.1
Coordinates 557712..557903 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J64_RS02795 (CHBNIII4_05360) 553291..553923 + 633 WP_005686927.1 dTMP kinase -
K6J64_RS02800 (CHBNIII4_05370) 553920..554903 + 984 WP_014550403.1 DNA polymerase III subunit delta' -
K6J64_RS02805 (CHBNIII4_05380) 554958..555740 + 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
K6J64_RS02810 (CHBNIII4_05390) 555767..556291 + 525 WP_005686921.1 DUF1523 family protein -
K6J64_RS02815 (CHBNIII4_05400) 556342..557640 + 1299 WP_014550404.1 hemolysin family protein -
K6J64_RS02820 (CHBNIII4_05410) 557712..557903 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
K6J64_RS02825 (CHBNIII4_05420) 557912..558049 + 138 WP_005686917.1 hypothetical protein Toxin
K6J64_RS02830 (CHBNIII4_05430) 558142..558672 + 531 WP_005662583.1 hypothetical protein -
K6J64_RS02835 (CHBNIII4_05440) 558744..560243 + 1500 WP_014550406.1 fused PTS fructose transporter subunit IIA/HPr protein -
K6J64_RS02840 (CHBNIII4_05450) 560245..561186 + 942 WP_014550407.1 1-phosphofructokinase -
K6J64_RS02845 (CHBNIII4_05460) 561188..562858 + 1671 WP_014550408.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T32172 WP_005686917.1 NZ_AP018775:557912-558049 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T32172 NZ_AP018775:557912-558049 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT32172 WP_005649350.1 NZ_AP018775:557712-557903 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT32172 NZ_AP018775:557712-557903 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References