Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1568437..1569026 Replicon chromosome
Accession NZ_AP018774
Organism Haemophilus influenzae strain CHBN-III-3 isolate 13H42

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J70_RS07605 Protein ID WP_005653200.1
Coordinates 1568778..1569026 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag K6J70_RS07600 Protein ID WP_005653201.1
Coordinates 1568437..1568781 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J70_RS07585 (CHBNIII3_14430) 1563660..1565054 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
K6J70_RS07590 (CHBNIII3_14440) 1565098..1565712 + 615 WP_005657019.1 riboflavin synthase -
K6J70_RS07595 (CHBNIII3_14450) 1565784..1568393 - 2610 WP_012054428.1 aminopeptidase N -
K6J70_RS07600 (CHBNIII3_14460) 1568437..1568781 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J70_RS07605 (CHBNIII3_14470) 1568778..1569026 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J70_RS07610 (CHBNIII3_14480) 1569197..1569691 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J70_RS07615 (CHBNIII3_14490) 1569761..1570849 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J70_RS07620 (CHBNIII3_14500) 1570989..1572179 + 1191 WP_005657030.1 amino acid aminotransferase -
K6J70_RS07625 (CHBNIII3_14510) 1572286..1572912 - 627 WP_012054430.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J70_RS07630 (CHBNIII3_14520) 1572914..1573546 - 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32166 WP_005653200.1 NZ_AP018774:c1569026-1568778 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32166 NZ_AP018774:c1569026-1568778 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT32166 WP_005653201.1 NZ_AP018774:c1568781-1568437 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT32166 NZ_AP018774:c1568781-1568437 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References