Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 689455..690092 Replicon chromosome
Accession NZ_AP018774
Organism Haemophilus influenzae strain CHBN-III-3 isolate 13H42

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag K6J70_RS03480 Protein ID WP_005659980.1
Coordinates 689455..689859 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag K6J70_RS03485 Protein ID WP_005656316.1
Coordinates 689856..690092 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J70_RS03450 (CHBNIII3_06630) 685016..685582 + 567 WP_005544066.1 elongation factor P -
K6J70_RS03460 (CHBNIII3_06640) 685934..686518 - 585 WP_005686764.1 primosomal replication protein -
K6J70_RS03465 (CHBNIII3_06650) 686550..687902 - 1353 WP_005686762.1 Na+/H+ antiporter family protein -
K6J70_RS03470 (CHBNIII3_06660) 688218..688907 - 690 WP_005686760.1 ribonuclease T -
K6J70_RS03475 (CHBNIII3_06670) 688981..689388 - 408 WP_005654069.1 lactoylglutathione lyase -
K6J70_RS03480 (CHBNIII3_06680) 689455..689859 - 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
K6J70_RS03485 (CHBNIII3_06690) 689856..690092 - 237 WP_005656316.1 antitoxin Antitoxin
K6J70_RS03490 (CHBNIII3_06700) 690185..690910 - 726 WP_005669008.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
K6J70_RS03495 (CHBNIII3_06710) 690963..691481 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
K6J70_RS03500 (CHBNIII3_06720) 691700..693466 + 1767 WP_011961734.1 aspartate--tRNA ligase -
K6J70_RS03505 (CHBNIII3_06730) 693528..694400 + 873 WP_048954586.1 hypothetical protein -
K6J70_RS08865 694603..694884 - 282 Protein_683 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T32164 WP_005659980.1 NZ_AP018774:c689859-689455 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T32164 NZ_AP018774:c689859-689455 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT32164 WP_005656316.1 NZ_AP018774:c690092-689856 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT32164 NZ_AP018774:c690092-689856 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References