Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 305663..306267 Replicon chromosome
Accession NZ_AP018774
Organism Haemophilus influenzae strain CHBN-III-3 isolate 13H42

Toxin (Protein)


Gene name relE Uniprot ID A0A112W1Q1
Locus tag K6J70_RS01530 Protein ID WP_005661261.1
Coordinates 305663..305971 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Y7JSS2
Locus tag K6J70_RS01535 Protein ID WP_005661259.1
Coordinates 305971..306267 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J70_RS01520 (CHBNIII3_02920) 300729..302027 - 1299 WP_005661950.1 trigger factor -
K6J70_RS08810 302328..302534 + 207 WP_126466921.1 PT domain-containing protein -
K6J70_RS08815 302443..302886 + 444 Protein_298 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
K6J70_RS01525 (CHBNIII3_02930) 303313..305607 + 2295 WP_246586739.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
K6J70_RS01530 (CHBNIII3_02940) 305663..305971 - 309 WP_005661261.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J70_RS01535 (CHBNIII3_02950) 305971..306267 - 297 WP_005661259.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J70_RS01540 (CHBNIII3_02960) 306387..307241 - 855 WP_005687862.1 DUF3298 domain-containing protein -
K6J70_RS01545 (CHBNIII3_02970) 307260..309119 - 1860 WP_012054618.1 selenocysteine-specific translation elongation factor -
K6J70_RS01550 (CHBNIII3_02980) 309116..310501 - 1386 WP_012054619.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11895.63 Da        Isoelectric Point: 7.3189

>T32160 WP_005661261.1 NZ_AP018774:c305971-305663 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T32160 NZ_AP018774:c305971-305663 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.37 Da        Isoelectric Point: 4.4297

>AT32160 WP_005661259.1 NZ_AP018774:c306267-305971 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT32160 NZ_AP018774:c306267-305971 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112W1Q1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Y7JSS2

References