Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1602171..1602815 | Replicon | chromosome |
| Accession | NZ_AP018773 | ||
| Organism | Haemophilus influenzae strain CHBN-III-2 isolate 13H39 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q4QKY0 |
| Locus tag | K6J68_RS07965 | Protein ID | WP_005643265.1 |
| Coordinates | 1602630..1602815 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q4QKX9 |
| Locus tag | K6J68_RS07960 | Protein ID | WP_005692602.1 |
| Coordinates | 1602171..1602599 (-) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J68_RS07920 (CHBNIII2_15110) | 1597582..1598550 | - | 969 | WP_110426138.1 | XRE family transcriptional regulator | - |
| K6J68_RS07925 (CHBNIII2_15120) | 1598684..1598890 | + | 207 | WP_006995067.1 | YdaS family helix-turn-helix protein | - |
| K6J68_RS07930 (CHBNIII2_15130) | 1598934..1599386 | + | 453 | WP_005651123.1 | hypothetical protein | - |
| K6J68_RS07935 (CHBNIII2_15140) | 1599432..1599665 | + | 234 | WP_005651121.1 | helix-turn-helix domain-containing protein | - |
| K6J68_RS07940 (CHBNIII2_15150) | 1599667..1600449 | + | 783 | WP_110459495.1 | helix-turn-helix domain-containing protein | - |
| K6J68_RS07945 (CHBNIII2_15160) | 1600434..1601069 | + | 636 | WP_011272502.1 | replication protein P | - |
| K6J68_RS07950 (CHBNIII2_15170) | 1601066..1601656 | + | 591 | WP_011272501.1 | DNA N-6-adenine-methyltransferase | - |
| K6J68_RS07955 (CHBNIII2_15180) | 1601661..1602170 | + | 510 | WP_005692600.1 | DUF1367 family protein | - |
| K6J68_RS07960 (CHBNIII2_15190) | 1602171..1602599 | - | 429 | WP_005692602.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K6J68_RS07965 | 1602630..1602815 | - | 186 | WP_005643265.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K6J68_RS07970 (CHBNIII2_15200) | 1602971..1603558 | + | 588 | WP_110426136.1 | recombination protein NinG | - |
| K6J68_RS07975 (CHBNIII2_15210) | 1603560..1603925 | + | 366 | WP_005651107.1 | antiterminator Q family protein | - |
| K6J68_RS07980 (CHBNIII2_15220) | 1604048..1604848 | + | 801 | WP_005692606.1 | hypothetical protein | - |
| K6J68_RS07985 (CHBNIII2_15230) | 1604859..1606007 | + | 1149 | WP_005651101.1 | type I restriction endonuclease | - |
| K6J68_RS07990 (CHBNIII2_15240) | 1606168..1606362 | + | 195 | WP_110426135.1 | hypothetical protein | - |
| K6J68_RS07995 (CHBNIII2_15250) | 1606748..1607059 | + | 312 | WP_005668736.1 | hypothetical protein | - |
| K6J68_RS08000 (CHBNIII2_15260) | 1607179..1607430 | + | 252 | WP_005688811.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1568785..1621189 | 52404 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6716.88 Da Isoelectric Point: 11.1595
>T32156 WP_005643265.1 NZ_AP018773:c1602815-1602630 [Haemophilus influenzae]
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
Download Length: 186 bp
>T32156 NZ_AP018773:c1602815-1602630 [Haemophilus influenzae]
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
Antitoxin
Download Length: 143 a.a. Molecular weight: 16458.45 Da Isoelectric Point: 4.3241
>AT32156 WP_005692602.1 NZ_AP018773:c1602599-1602171 [Haemophilus influenzae]
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
Download Length: 429 bp
>AT32156 NZ_AP018773:c1602599-1602171 [Haemophilus influenzae]
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|