32153

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 564454..564782 Replicon chromosome
Accession NZ_AP018773
Organism Haemophilus influenzae strain CHBN-III-2 isolate 13H39

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag K6J68_RS02835 Protein ID WP_005686917.1
Coordinates 564645..564782 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID -
Locus tag K6J68_RS02830 Protein ID WP_050822814.1
Coordinates 564454..564636 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J68_RS02805 (CHBNIII2_05400) 560033..560665 + 633 WP_005686927.1 dTMP kinase -
K6J68_RS02810 (CHBNIII2_05410) 560662..561645 + 984 WP_110459482.1 DNA polymerase III subunit delta' -
K6J68_RS02815 (CHBNIII2_05420) 561700..562482 + 783 WP_005662581.1 YchF/TatD family DNA exonuclease -
K6J68_RS02820 (CHBNIII2_05430) 562509..563033 + 525 WP_005656502.1 DUF1523 family protein -
K6J68_RS02825 (CHBNIII2_05440) 563084..564382 + 1299 WP_075985482.1 hemolysin family protein -
K6J68_RS02830 (CHBNIII2_05450) 564454..564636 + 183 WP_050822814.1 DUF5397 family protein Antitoxin
K6J68_RS02835 (CHBNIII2_05460) 564645..564782 + 138 WP_005686917.1 hypothetical protein Toxin
K6J68_RS02840 (CHBNIII2_05470) 564875..565405 + 531 WP_005686915.1 hypothetical protein -
K6J68_RS02845 (CHBNIII2_05480) 565477..566976 + 1500 WP_005686912.1 fused PTS fructose transporter subunit IIA/HPr protein -
K6J68_RS02850 (CHBNIII2_05490) 566978..567919 + 942 WP_005686910.1 1-phosphofructokinase -
K6J68_RS02855 (CHBNIII2_05500) 567921..569591 + 1671 WP_005686908.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-60)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T32153 WP_005686917.1 NZ_AP018773:564645-564782 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T32153 NZ_AP018773:564645-564782 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6730.71 Da        Isoelectric Point: 3.9930

>AT32153 WP_050822814.1 NZ_AP018773:564454-564636 [Haemophilus influenzae]
MELRQQIPTGCIKQFGVPYVVGEVAEFLLDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 183 bp

>AT32153 NZ_AP018773:564454-564636 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGTTGCGGAATT
TTTGCTAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTATCTCACCTAC
TTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure

References