Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 306262..306866 Replicon chromosome
Accession NZ_AP018773
Organism Haemophilus influenzae strain CHBN-III-2 isolate 13H39

Toxin (Protein)


Gene name relE Uniprot ID A0A112W1Q1
Locus tag K6J68_RS01540 Protein ID WP_005661261.1
Coordinates 306262..306570 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Y7JSS2
Locus tag K6J68_RS01545 Protein ID WP_005661259.1
Coordinates 306570..306866 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J68_RS01530 (CHBNIII2_02930) 301301..302599 - 1299 WP_005658620.1 trigger factor -
K6J68_RS09530 302931..303029 + 99 Protein_298 PT domain-containing protein -
K6J68_RS09535 303018..303083 + 66 Protein_299 PT domain-containing protein -
K6J68_RS09540 303053..303136 + 84 Protein_300 PT domain-containing protein -
K6J68_RS09545 303107..303488 + 382 Protein_301 TonB-dependent receptor plug domain-containing protein -
K6J68_RS01535 (CHBNIII2_02940) 303915..306206 + 2292 WP_233993457.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
K6J68_RS01540 (CHBNIII2_02950) 306262..306570 - 309 WP_005661261.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J68_RS01545 (CHBNIII2_02960) 306570..306866 - 297 WP_005661259.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J68_RS01550 (CHBNIII2_02970) 306986..307840 - 855 WP_005687862.1 DUF3298 domain-containing protein -
K6J68_RS01555 (CHBNIII2_02980) 307859..309718 - 1860 WP_005687864.1 selenocysteine-specific translation elongation factor -
K6J68_RS01560 (CHBNIII2_02990) 309715..311100 - 1386 WP_005687866.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hgpC / hgpC 302902..312599 9697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11895.63 Da        Isoelectric Point: 7.3189

>T32150 WP_005661261.1 NZ_AP018773:c306570-306262 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T32150 NZ_AP018773:c306570-306262 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.37 Da        Isoelectric Point: 4.4297

>AT32150 WP_005661259.1 NZ_AP018773:c306866-306570 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT32150 NZ_AP018773:c306866-306570 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112W1Q1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Y7JSS2

References