Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46027..46658 Replicon chromosome
Accession NZ_AP018773
Organism Haemophilus influenzae strain CHBN-III-2 isolate 13H39

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag K6J68_RS00225 Protein ID WP_005651560.1
Coordinates 46260..46658 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag K6J68_RS00220 Protein ID WP_005648011.1
Coordinates 46027..46260 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J68_RS00195 (CHBNIII2_00390) 41507..42709 - 1203 WP_105197740.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
K6J68_RS00200 (CHBNIII2_00400) 42873..43538 + 666 WP_041174703.1 DNA repair protein RadC -
K6J68_RS00205 (CHBNIII2_00410) 43751..43987 + 237 WP_005542826.1 50S ribosomal protein L28 -
K6J68_RS00210 (CHBNIII2_00420) 43999..44169 + 171 WP_005613503.1 50S ribosomal protein L33 -
K6J68_RS00215 (CHBNIII2_00430) 44516..45880 + 1365 WP_005664172.1 diaminobutyrate--2-oxoglutarate transaminase -
K6J68_RS00220 (CHBNIII2_00440) 46027..46260 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
K6J68_RS00225 (CHBNIII2_00450) 46260..46658 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
K6J68_RS00230 (CHBNIII2_00460) 46678..48213 + 1536 WP_012054543.1 L-2,4-diaminobutyrate decarboxylase -
K6J68_RS00235 (CHBNIII2_00470) 48444..49259 + 816 WP_012054544.1 DNA-formamidopyrimidine glycosylase -
K6J68_RS00240 (CHBNIII2_00480) 49333..50355 - 1023 WP_005651554.1 outer membrane-stress sensor serine endopeptidase DegS -
K6J68_RS00245 (CHBNIII2_00490) 50356..51474 - 1119 WP_005686201.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T32148 WP_005651560.1 NZ_AP018773:46260-46658 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T32148 NZ_AP018773:46260-46658 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT32148 WP_005648011.1 NZ_AP018773:46027-46260 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT32148 NZ_AP018773:46027-46260 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References