Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 692000..692637 Replicon chromosome
Accession NZ_AP018772
Organism Haemophilus influenzae strain CHBN-III-1 isolate 15H02

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag K6J58_RS03500 Protein ID WP_005659980.1
Coordinates 692000..692404 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag K6J58_RS03505 Protein ID WP_005656316.1
Coordinates 692401..692637 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J58_RS03470 (CHBNIII1_06720) 687561..688127 + 567 WP_005544066.1 elongation factor P -
K6J58_RS03480 (CHBNIII1_06730) 688479..689063 - 585 WP_005686764.1 primosomal replication protein -
K6J58_RS03485 (CHBNIII1_06740) 689095..690447 - 1353 WP_005686762.1 Na+/H+ antiporter family protein -
K6J58_RS03490 (CHBNIII1_06750) 690763..691452 - 690 WP_005686760.1 ribonuclease T -
K6J58_RS03495 (CHBNIII1_06760) 691526..691933 - 408 WP_112075280.1 lactoylglutathione lyase -
K6J58_RS03500 (CHBNIII1_06770) 692000..692404 - 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
K6J58_RS03505 (CHBNIII1_06780) 692401..692637 - 237 WP_005656316.1 antitoxin Antitoxin
K6J58_RS03510 (CHBNIII1_06790) 692730..693455 - 726 WP_005669008.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
K6J58_RS03515 (CHBNIII1_06800) 693508..694026 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
K6J58_RS03520 (CHBNIII1_06810) 694245..696011 + 1767 WP_005686757.1 aspartate--tRNA ligase -
K6J58_RS03525 (CHBNIII1_06820) 696033..696509 + 477 WP_005686755.1 dihydroneopterin triphosphate diphosphatase -
K6J58_RS03530 (CHBNIII1_06830) 696669..697409 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T32145 WP_005659980.1 NZ_AP018772:c692404-692000 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T32145 NZ_AP018772:c692404-692000 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT32145 WP_005656316.1 NZ_AP018772:c692637-692401 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT32145 NZ_AP018772:c692637-692401 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References