Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 566597..566934 Replicon chromosome
Accession NZ_AP018772
Organism Haemophilus influenzae strain CHBN-III-1 isolate 15H02

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag K6J58_RS02845 Protein ID WP_005686917.1
Coordinates 566797..566934 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag K6J58_RS02840 Protein ID WP_005649350.1
Coordinates 566597..566788 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J58_RS02815 (CHBNIII1_05460) 562176..562808 + 633 WP_005686927.1 dTMP kinase -
K6J58_RS02820 (CHBNIII1_05470) 562805..563788 + 984 WP_005686925.1 DNA polymerase III subunit delta' -
K6J58_RS02825 (CHBNIII1_05480) 563843..564625 + 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
K6J58_RS02830 (CHBNIII1_05490) 564652..565176 + 525 WP_005686921.1 DUF1523 family protein -
K6J58_RS02835 (CHBNIII1_05500) 565227..566525 + 1299 WP_032821624.1 hemolysin family protein -
K6J58_RS02840 (CHBNIII1_05510) 566597..566788 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
K6J58_RS02845 (CHBNIII1_05520) 566797..566934 + 138 WP_005686917.1 hypothetical protein Toxin
K6J58_RS02850 (CHBNIII1_05530) 567027..567557 + 531 WP_005686915.1 hypothetical protein -
K6J58_RS02855 (CHBNIII1_05540) 567629..569128 + 1500 WP_005686912.1 fused PTS fructose transporter subunit IIA/HPr protein -
K6J58_RS02860 (CHBNIII1_05550) 569130..570071 + 942 WP_005686910.1 1-phosphofructokinase -
K6J58_RS02865 (CHBNIII1_05560) 570073..571743 + 1671 WP_005686908.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T32144 WP_005686917.1 NZ_AP018772:566797-566934 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T32144 NZ_AP018772:566797-566934 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT32144 WP_005649350.1 NZ_AP018772:566597-566788 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT32144 NZ_AP018772:566597-566788 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References