Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 305913..306517 Replicon chromosome
Accession NZ_AP018772
Organism Haemophilus influenzae strain CHBN-III-1 isolate 15H02

Toxin (Protein)


Gene name relE Uniprot ID A0A112W1Q1
Locus tag K6J58_RS01530 Protein ID WP_005661261.1
Coordinates 305913..306221 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Y7JSS2
Locus tag K6J58_RS01535 Protein ID WP_005661259.1
Coordinates 306221..306517 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J58_RS01520 (CHBNIII1_02940) 300946..302244 - 1299 WP_005658620.1 trigger factor -
K6J58_RS08830 302547..302825 + 279 WP_246589434.1 PT domain-containing protein -
K6J58_RS01525 (CHBNIII1_02950) 302864..305857 + 2994 WP_246589443.1 TonB-dependent receptor -
K6J58_RS01530 (CHBNIII1_02960) 305913..306221 - 309 WP_005661261.1 type II toxin-antitoxin system YafQ family toxin Toxin
K6J58_RS01535 (CHBNIII1_02970) 306221..306517 - 297 WP_005661259.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J58_RS01540 (CHBNIII1_02980) 306637..307491 - 855 WP_005687862.1 DUF3298 domain-containing protein -
K6J58_RS01545 (CHBNIII1_02990) 307510..309369 - 1860 WP_005687864.1 selenocysteine-specific translation elongation factor -
K6J58_RS01550 (CHBNIII1_03000) 309366..310751 - 1386 WP_005687866.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hgpC / hgpC 302547..312250 9703


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11895.63 Da        Isoelectric Point: 7.3189

>T32141 WP_005661261.1 NZ_AP018772:c306221-305913 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T32141 NZ_AP018772:c306221-305913 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.37 Da        Isoelectric Point: 4.4297

>AT32141 WP_005661259.1 NZ_AP018772:c306517-306221 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT32141 NZ_AP018772:c306517-306221 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112W1Q1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Y7JSS2

References