Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1592131..1592775 | Replicon | chromosome |
| Accession | NZ_AP018771 | ||
| Organism | Haemophilus influenzae strain CHBN-II-8 isolate 10H27 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q4QKY0 |
| Locus tag | K6J66_RS07980 | Protein ID | WP_005643265.1 |
| Coordinates | 1592131..1592316 (+) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q4QKX9 |
| Locus tag | K6J66_RS07985 | Protein ID | WP_005692602.1 |
| Coordinates | 1592347..1592775 (+) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J66_RS07940 (CHBNII8_15140) | 1588224..1588697 | - | 474 | WP_042594852.1 | DUF1441 family protein | - |
| K6J66_RS07945 (CHBNII8_15150) | 1588974..1589363 | - | 390 | WP_042600478.1 | hypothetical protein | - |
| K6J66_RS07950 (CHBNII8_15160) | 1589405..1589686 | - | 282 | WP_110442488.1 | hypothetical protein | - |
| K6J66_RS07955 (CHBNII8_15170) | 1589598..1589933 | - | 336 | WP_110442489.1 | DUF2570 family protein | - |
| K6J66_RS07960 (CHBNII8_15180) | 1589906..1590448 | - | 543 | WP_110442490.1 | lysozyme | - |
| K6J66_RS07965 (CHBNII8_15190) | 1590429..1590680 | - | 252 | WP_005688862.1 | hypothetical protein | - |
| K6J66_RS07970 (CHBNII8_15200) | 1590920..1591429 | - | 510 | WP_105872415.1 | antiterminator Q family protein | - |
| K6J66_RS07975 (CHBNII8_15210) | 1591430..1591975 | - | 546 | WP_005668550.1 | recombination protein NinG | - |
| K6J66_RS07980 | 1592131..1592316 | + | 186 | WP_005643265.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K6J66_RS07985 (CHBNII8_15220) | 1592347..1592775 | + | 429 | WP_005692602.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K6J66_RS07990 (CHBNII8_15230) | 1592776..1593285 | - | 510 | WP_110442491.1 | DUF1367 family protein | - |
| K6J66_RS07995 (CHBNII8_15240) | 1593290..1593880 | - | 591 | WP_110442492.1 | DNA N-6-adenine-methyltransferase | - |
| K6J66_RS08000 (CHBNII8_15250) | 1593877..1594518 | - | 642 | WP_110442493.1 | replication protein P | - |
| K6J66_RS08005 (CHBNII8_15260) | 1594503..1595261 | - | 759 | WP_110442494.1 | helix-turn-helix domain-containing protein | - |
| K6J66_RS08010 (CHBNII8_15270) | 1595258..1595932 | - | 675 | WP_011272606.1 | phage antirepressor KilAC domain-containing protein | - |
| K6J66_RS08015 (CHBNII8_15280) | 1595981..1596421 | - | 441 | WP_005651303.1 | YmfL family putative regulatory protein | - |
| K6J66_RS08020 (CHBNII8_15290) | 1596470..1596673 | - | 204 | WP_005651305.1 | YdaS family helix-turn-helix protein | - |
| K6J66_RS08025 (CHBNII8_15300) | 1596795..1597550 | + | 756 | WP_005668731.1 | S24 family peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1555663..1609639 | 53976 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6716.88 Da Isoelectric Point: 11.1595
>T32137 WP_005643265.1 NZ_AP018771:1592131-1592316 [Haemophilus influenzae]
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
MRSSDLIKELKSAGCTFVRHGKGDHQIWQSPITGKTFPVPHPKQHVPIGTLRSIKKSAGLL
Download Length: 186 bp
>T32137 NZ_AP018771:1592131-1592316 [Haemophilus influenzae]
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
ATGCGATCCAGCGACTTAATCAAGGAACTTAAAAGTGCAGGTTGTACTTTTGTCAGGCACGGTAAAGGCGATCATCAAAT
CTGGCAATCGCCCATCACAGGGAAGACGTTCCCCGTACCGCATCCAAAACAACACGTACCCATCGGCACATTAAGATCCA
TCAAAAAATCGGCAGGGCTTCTATAG
Antitoxin
Download Length: 143 a.a. Molecular weight: 16458.45 Da Isoelectric Point: 4.3241
>AT32137 WP_005692602.1 NZ_AP018771:1592347-1592775 [Haemophilus influenzae]
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
MLFTIGIETPTNENEAYGITVPALFTEEYSCFSAADTLEEIPTQVTDAIHSILEMMFEDGIDINELQDKGYRHYQTQEDF
NYCDTWLLLDVDISAYQGKRHRINISLPEYLIKRIDSRVASNPIYKDRSHFLAIASQKELRQ
Download Length: 429 bp
>AT32137 NZ_AP018771:1592347-1592775 [Haemophilus influenzae]
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
ATGTTATTCACTATCGGCATTGAAACCCCAACAAACGAAAATGAAGCCTACGGCATTACGGTGCCAGCATTATTTACTGA
AGAATATTCCTGCTTTAGTGCCGCTGATACCCTTGAGGAAATCCCAACGCAGGTGACTGATGCCATTCATTCCATCTTAG
AAATGATGTTTGAAGACGGAATAGACATCAACGAACTTCAAGATAAAGGCTATCGTCACTACCAAACGCAAGAAGATTTC
AACTATTGCGATACTTGGTTGTTGCTTGATGTAGATATTTCCGCATATCAAGGCAAACGCCACCGTATTAATATCAGCTT
GCCTGAATACCTTATCAAACGTATTGATAGCCGTGTTGCAAGCAATCCAATCTACAAAGACCGCAGCCACTTTTTAGCGA
TTGCCTCACAAAAAGAGCTACGGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|