Detailed information of TA system TA032132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 303732..304336
• Replicon: chromosome
• Accession: NZ_AP018771
• Organism: Haemophilus influenzae strain CHBN-II-8 isolate 10H27

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K6J66_RS01510
• Protein ID: WP_040035583.1
• Coordinates: 303732..304040 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4QMK8
• Locus tag: K6J66_RS01515
• Protein ID: WP_005692346.1
• Coordinates: 304040..304336 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J66_RS01500 (CHBNII8_02900)	298865..300166	-	1302	WP_110442613.1	trigger factor	-
K6J66_RS09550	300533..300640	+	108	WP_236747310.1	PT domain-containing protein	-
K6J66_RS09555	300591..300972	+	382	Protein_293	TonB-dependent receptor plug domain-containing protein	-
K6J66_RS01505 (CHBNII8_02910)	301399..303675	+	2277	WP_246587796.1	TonB-dependent receptor	-
K6J66_RS01510 (CHBNII8_02920)	303732..304040	-	309	WP_040035583.1	type II toxin-antitoxin system YafQ family toxin	Toxin
K6J66_RS01515 (CHBNII8_02930)	304040..304336	-	297	WP_005692346.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K6J66_RS01520 (CHBNII8_02940)	304456..305310	-	855	WP_015701818.1	DUF3298 domain-containing protein	-
K6J66_RS01525 (CHBNII8_02950)	305329..307188	-	1860	WP_110442588.1	selenocysteine-specific translation elongation factor	-
K6J66_RS01530 (CHBNII8_02960)	307185..308570	-	1386	WP_110442587.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11867.62 Da
• Isoelectric Point: 7.8941

>T32132 WP_040035583.1 NZ_AP018771:c304040-303732 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPESYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T32132 NZ_AP018771:c304040-303732 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAGCTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTAATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11003.27 Da
• Isoelectric Point: 4.2845

>AT32132 WP_005692346.1 NZ_AP018771:c304336-304040 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT32132 NZ_AP018771:c304336-304040 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Structures

Antitoxin

• AlphaFold DB: Q4QMK8