Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1641049..1641638 Replicon chromosome
Accession NZ_AP018770
Organism Haemophilus influenzae strain CHBN-II-7 isolate 13H35

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J57_RS08215 Protein ID WP_005653200.1
Coordinates 1641390..1641638 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag K6J57_RS08210 Protein ID WP_005653201.1
Coordinates 1641049..1641393 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J57_RS08195 (CHBNII7_15660) 1636272..1637666 - 1395 WP_042599651.1 sodium-coupled multidrug efflux MATE transporter HmrM -
K6J57_RS08200 (CHBNII7_15670) 1637710..1638324 + 615 WP_042599650.1 riboflavin synthase -
K6J57_RS08205 (CHBNII7_15680) 1638396..1641005 - 2610 WP_042593851.1 aminopeptidase N -
K6J57_RS08210 (CHBNII7_15690) 1641049..1641393 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J57_RS08215 (CHBNII7_15700) 1641390..1641638 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J57_RS08220 (CHBNII7_15710) 1641809..1642303 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J57_RS08225 (CHBNII7_15720) 1642373..1643461 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J57_RS08230 (CHBNII7_15730) 1643601..1644791 + 1191 WP_005657030.1 amino acid aminotransferase -
K6J57_RS08235 (CHBNII7_15740) 1644898..1645524 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J57_RS08240 (CHBNII7_15750) 1645526..1646158 - 633 WP_005660550.1 energy-coupling factor transporter transmembrane component T -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32131 WP_005653200.1 NZ_AP018770:c1641638-1641390 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32131 NZ_AP018770:c1641638-1641390 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT32131 WP_005653201.1 NZ_AP018770:c1641393-1641049 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT32131 NZ_AP018770:c1641393-1641049 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References