Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1569000..1569589 Replicon chromosome
Accession NZ_AP018768
Organism Haemophilus influenzae strain CHBN-II-5 isolate 13H40

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J56_RS07715 Protein ID WP_005653200.1
Coordinates 1569341..1569589 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag K6J56_RS07710 Protein ID WP_005653201.1
Coordinates 1569000..1569344 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J56_RS07695 (CHBNII5_14640) 1564223..1565617 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
K6J56_RS07700 (CHBNII5_14650) 1565661..1566275 + 615 WP_005657019.1 riboflavin synthase -
K6J56_RS07705 (CHBNII5_14660) 1566347..1568956 - 2610 WP_044364349.1 aminopeptidase N -
K6J56_RS07710 (CHBNII5_14670) 1569000..1569344 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J56_RS07715 (CHBNII5_14680) 1569341..1569589 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J56_RS07720 (CHBNII5_14690) 1569760..1570254 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J56_RS07725 (CHBNII5_14700) 1570324..1571412 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J56_RS07730 (CHBNII5_14710) 1571552..1572742 + 1191 WP_038439961.1 amino acid aminotransferase -
K6J56_RS07735 (CHBNII5_14720) 1572847..1573473 - 627 WP_005671598.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J56_RS07740 (CHBNII5_14730) 1573475..1574107 - 633 WP_032824077.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32118 WP_005653200.1 NZ_AP018768:c1569589-1569341 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32118 NZ_AP018768:c1569589-1569341 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT32118 WP_005653201.1 NZ_AP018768:c1569344-1569000 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT32118 NZ_AP018768:c1569344-1569000 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References