Detailed information of TA system TA032107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 387028..387499
• Replicon: chromosome
• Accession: NZ_AP018767
• Organism: Haemophilus influenzae strain CHBN-II-4 isolate 13H33

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: K6J55_RS01895
• Protein ID: WP_005654546.1
• Coordinates: 387028..387210 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: K6J55_RS01900
• Protein ID: WP_005650837.1
• Coordinates: 387203..387499 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6J55_RS01885 (CHBNII4_03510)	383057..383296	-	240	WP_105893696.1	hypothetical protein	-
K6J55_RS09035	383808..383954	+	147	WP_246586457.1	PT domain-containing protein	-
K6J55_RS01890 (CHBNII4_03520)	383885..386758	+	2874	Protein_357	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
K6J55_RS01895 (CHBNII4_03530)	387028..387210	+	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
K6J55_RS01900 (CHBNII4_03540)	387203..387499	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
K6J55_RS01905 (CHBNII4_03550)	387666..389582	+	1917	WP_048942740.1	ABC transporter ATP-binding protein	-
K6J55_RS01910 (CHBNII4_03560)	389592..390140	+	549	WP_048942741.1	type I DNA topoisomerase	-
K6J55_RS01915 (CHBNII4_03570)	390156..390707	+	552	WP_048942742.1	Sua5/YciO/YrdC/YwlC family protein	-
K6J55_RS01920 (CHBNII4_03580)	390711..391517	+	807	WP_048942743.1	shikimate dehydrogenase	-
K6J55_RS01925 (CHBNII4_03590)	391731..392294	+	564	WP_048942744.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T32107 WP_005654546.1 NZ_AP018767:387028-387210 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T32107 NZ_AP018767:387028-387210 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAATATCTGCTATCGCTGGCTCAAAATGA
AAGTAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT32107 WP_005650837.1 NZ_AP018767:387203-387499 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT32107 NZ_AP018767:387203-387499 [Haemophilus influenzae]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9