32098

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1742501..1743090 Replicon chromosome
Accession NZ_AP018765
Organism Haemophilus influenzae strain CHBN-II-2 isolate 12H49

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J63_RS08865 Protein ID WP_005653200.1
Coordinates 1742842..1743090 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag K6J63_RS08860 Protein ID WP_005653201.1
Coordinates 1742501..1742845 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J63_RS08845 (CHBNII2_16980) 1737724..1739118 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
K6J63_RS08850 (CHBNII2_16990) 1739162..1739776 + 615 WP_005657019.1 riboflavin synthase -
K6J63_RS08855 (CHBNII2_17000) 1739848..1742457 - 2610 WP_011272463.1 aminopeptidase N -
K6J63_RS08860 (CHBNII2_17010) 1742501..1742845 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J63_RS08865 (CHBNII2_17020) 1742842..1743090 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J63_RS08870 (CHBNII2_17030) 1743261..1743755 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J63_RS08875 (CHBNII2_17040) 1743825..1744913 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J63_RS08880 (CHBNII2_17050) 1745053..1746243 + 1191 WP_005657030.1 amino acid aminotransferase -
K6J63_RS08885 (CHBNII2_17060) 1746350..1746976 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J63_RS08890 (CHBNII2_17070) 1746978..1747610 - 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32098 WP_005653200.1 NZ_AP018765:c1743090-1742842 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32098 NZ_AP018765:c1743090-1742842 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT32098 WP_005653201.1 NZ_AP018765:c1742845-1742501 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT32098 NZ_AP018765:c1742845-1742501 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References