Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1742433..1743022 Replicon chromosome
Accession NZ_AP018764
Organism Haemophilus influenzae strain CHBN-II-1 isolate 13H34

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag K6J65_RS08855 Protein ID WP_005653200.1
Coordinates 1742774..1743022 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag K6J65_RS08850 Protein ID WP_005653201.1
Coordinates 1742433..1742777 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J65_RS08835 (CHBNII1_16980) 1737656..1739050 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
K6J65_RS08840 (CHBNII1_16990) 1739094..1739708 + 615 WP_005657019.1 riboflavin synthase -
K6J65_RS08845 (CHBNII1_17000) 1739780..1742389 - 2610 WP_011272463.1 aminopeptidase N -
K6J65_RS08850 (CHBNII1_17010) 1742433..1742777 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6J65_RS08855 (CHBNII1_17020) 1742774..1743022 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
K6J65_RS08860 (CHBNII1_17030) 1743193..1743687 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K6J65_RS08865 (CHBNII1_17040) 1743757..1744845 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
K6J65_RS08870 (CHBNII1_17050) 1744985..1746175 + 1191 WP_005657030.1 amino acid aminotransferase -
K6J65_RS08875 (CHBNII1_17060) 1746282..1746908 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
K6J65_RS08880 (CHBNII1_17070) 1746910..1747542 - 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T32091 WP_005653200.1 NZ_AP018764:c1743022-1742774 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T32091 NZ_AP018764:c1743022-1742774 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT32091 WP_005653201.1 NZ_AP018764:c1742777-1742433 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT32091 NZ_AP018764:c1742777-1742433 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References