Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 888356..888890 Replicon chromosome
Accession NZ_AP018764
Organism Haemophilus influenzae strain CHBN-II-1 isolate 13H34

Toxin (Protein)


Gene name relE Uniprot ID A0A0M1GMI0
Locus tag K6J65_RS04695 Protein ID WP_012054909.1
Coordinates 888600..888890 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0M1GP19
Locus tag K6J65_RS04690 Protein ID WP_032823666.1
Coordinates 888356..888610 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J65_RS04650 (CHBNII1_08960) 883552..883779 + 228 WP_048950149.1 hypothetical protein -
K6J65_RS04655 (CHBNII1_08970) 883822..884037 + 216 WP_032823658.1 AlpA family phage regulatory protein -
K6J65_RS04660 (CHBNII1_08980) 884018..884248 + 231 WP_012054915.1 hypothetical protein -
K6J65_RS04665 884308..884901 + 594 WP_105886805.1 host cell division inhibitor Icd-like protein -
K6J65_RS04670 (CHBNII1_08990) 884894..885133 + 240 WP_105886806.1 hypothetical protein -
K6J65_RS04675 (CHBNII1_09000) 885130..885354 + 225 WP_105886807.1 hypothetical protein -
K6J65_RS04680 (CHBNII1_09010) 885363..885641 + 279 WP_105886808.1 hypothetical protein -
K6J65_RS04685 (CHBNII1_09020) 885651..887858 + 2208 WP_105886809.1 DUF927 domain-containing protein -
K6J65_RS04690 (CHBNII1_09030) 888356..888610 + 255 WP_032823666.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6J65_RS04695 (CHBNII1_09040) 888600..888890 + 291 WP_012054909.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J65_RS04700 (CHBNII1_09050) 889491..889814 - 324 WP_005653397.1 ribosome-associated translation inhibitor RaiA -
K6J65_RS04705 (CHBNII1_09060) 890004..890633 - 630 WP_038439193.1 outer membrane protein assembly factor BamC -
K6J65_RS04710 (CHBNII1_09070) 890744..891640 - 897 WP_050846026.1 4-hydroxy-tetrahydrodipicolinate synthase -
K6J65_RS04715 (CHBNII1_09080) 891741..892208 + 468 WP_005668209.1 thioredoxin-dependent thiol peroxidase -
K6J65_RS04720 (CHBNII1_09090) 892377..892829 + 453 WP_005648856.1 TonB-system energizer ExbB -
K6J65_RS04725 (CHBNII1_09100) 892833..893276 + 444 WP_005648853.1 TonB system transport protein ExbD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lgtC 876514..890633 14119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11237.15 Da        Isoelectric Point: 10.4256

>T32089 WP_012054909.1 NZ_AP018764:888600-888890 [Haemophilus influenzae]
MTYKLTFSPKAKKEWDKLGDTIKNQFKKKLLERLENPHVPADRLSGFSGVFYKIKLRSVGYRLVYEVIEDKVIVYVLAVG
KRERAEVYTAARDRLN

Download         Length: 291 bp

>T32089 NZ_AP018764:888600-888890 [Haemophilus influenzae]
ATGACTTATAAACTGACATTTAGCCCAAAGGCAAAGAAAGAATGGGATAAACTTGGCGATACCATAAAAAACCAATTTAA
GAAAAAGTTATTAGAACGCTTAGAAAATCCACACGTGCCAGCAGATCGGCTTTCTGGCTTTTCTGGAGTGTTTTATAAAA
TAAAACTTCGCTCGGTAGGTTATCGTTTAGTTTATGAAGTTATTGAAGATAAAGTTATCGTTTATGTTCTTGCCGTTGGC
AAGCGTGAACGCGCTGAAGTTTACACCGCTGCACGCGATAGATTAAATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9526.91 Da        Isoelectric Point: 4.1317

>AT32089 WP_032823666.1 NZ_AP018764:888356-888610 [Haemophilus influenzae]
MAIHQILTEQAASITDLKRNPMGVMRESENGVIAILNRNQPAFYCLTPEMFAYMQELIEDAELVRIAEERKAEGGFIEVD
INDL

Download         Length: 255 bp

>AT32089 NZ_AP018764:888356-888610 [Haemophilus influenzae]
ATGGCAATTCATCAAATACTAACAGAGCAGGCTGCAAGCATTACCGATCTAAAACGAAACCCTATGGGCGTAATGCGAGA
AAGTGAAAATGGCGTGATTGCTATATTAAATCGTAACCAACCAGCCTTTTATTGTCTTACGCCTGAAATGTTCGCTTATA
TGCAAGAATTAATCGAAGATGCAGAACTAGTACGCATTGCAGAAGAGCGAAAAGCTGAGGGCGGTTTTATTGAGGTTGAT
ATTAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M1GMI0

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GP19

References