Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46458..47089 Replicon chromosome
Accession NZ_AP018764
Organism Haemophilus influenzae strain CHBN-II-1 isolate 13H34

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag K6J65_RS00220 Protein ID WP_005651560.1
Coordinates 46691..47089 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag K6J65_RS00215 Protein ID WP_005648011.1
Coordinates 46458..46691 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J65_RS00190 (CHBNII1_00380) 41938..43140 - 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
K6J65_RS00195 (CHBNII1_00390) 43303..43968 + 666 WP_013526173.1 DNA repair protein RadC -
K6J65_RS00200 (CHBNII1_00400) 44182..44418 + 237 WP_005542826.1 50S ribosomal protein L28 -
K6J65_RS00205 (CHBNII1_00410) 44430..44600 + 171 WP_005613503.1 50S ribosomal protein L33 -
K6J65_RS00210 (CHBNII1_00420) 44947..46311 + 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
K6J65_RS00215 (CHBNII1_00430) 46458..46691 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
K6J65_RS00220 (CHBNII1_00440) 46691..47089 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
K6J65_RS00225 (CHBNII1_00450) 47109..48644 + 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
K6J65_RS00230 (CHBNII1_00460) 49086..49349 + 264 WP_032823788.1 hypothetical protein -
K6J65_RS00235 (CHBNII1_00470) 49389..50234 - 846 WP_048951895.1 hypothetical protein -
K6J65_RS00240 50296..50415 - 120 WP_005641687.1 Com family DNA-binding transcriptional regulator -
K6J65_RS00245 (CHBNII1_00480) 50590..51078 - 489 WP_136439033.1 enoyl-CoA hydratase -
K6J65_RS00250 (CHBNII1_00490) 51071..51697 - 627 WP_105886750.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T32085 WP_005651560.1 NZ_AP018764:46691-47089 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T32085 NZ_AP018764:46691-47089 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT32085 WP_005648011.1 NZ_AP018764:46458-46691 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT32085 NZ_AP018764:46458-46691 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References