Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 82053..82696 Replicon plasmid pMRY16-398_1
Accession NZ_AP018757
Organism Metakosakonia sp. MRY16-398

Toxin (Protein)


Gene name vagD Uniprot ID A0A348DMH6
Locus tag MRY16398_RS29390 Protein ID WP_047368852.1
Coordinates 82053..82469 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A348DMH7
Locus tag MRY16398_RS29395 Protein ID WP_047368851.1
Coordinates 82466..82696 (-) Length 77 a.a.

Genomic Context

MRY16398_RS29380MRY16398_RS29385MRY16398_RS29400MRY16398_RS29405MRY16398_RS29390MRY16398_RS29395MRY16398_RS29410MRY16398_RS29415MRY16398_RS29420MRY16398_RS29425
Location: 78828..79070 (243 bp)
Type: Others
Protein ID: WP_047368854.1
Location: 80637..81866 (1230 bp)
Type: Others
Protein ID: WP_047368853.1
Location: 83041..83301 (261 bp)
Type: Others
Protein ID: WP_007374405.1
Location: 83288..83584 (297 bp)
Type: Others
Protein ID: WP_047368850.1
Location: 82053..82469 (417 bp)
Type: Toxin
Protein ID: WP_047368852.1
Location: 82466..82696 (231 bp)
Type: Antitoxin
Protein ID: WP_047368851.1
Location: 83814..84248 (435 bp)
Type: Others
Protein ID: WP_007374421.1
Location: 84466..85866 (1401 bp)
Type: Others
Protein ID: WP_007374420.1
Location: 85863..86543 (681 bp)
Type: Others
Protein ID: WP_001188930.1
Location: 86598..87527 (930 bp)
Type: Others
Protein ID: WP_000998778.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MRY16398_RS2938078828..79070+243WP_047368854.1hypothetical protein-
MRY16398_RS2938580637..81866+1230WP_047368853.1HDOD domain-containing protein-
MRY16398_RS2939082053..82469-417WP_047368852.1type II toxin-antitoxin system VapC family toxinToxin
MRY16398_RS2939582466..82696-231WP_047368851.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MRY16398_RS2940083041..83301+261WP_007374405.1type II toxin-antitoxin system ParD family antitoxin-
MRY16398_RS2940583288..83584+297WP_047368850.1type II toxin-antitoxin system RelE/ParE family toxin-
MRY16398_RS2941083814..84248-435WP_007374421.1hypothetical protein-
MRY16398_RS2941584466..85866-1401WP_007374420.1copper resistance membrane spanning protein PcoS-
MRY16398_RS2942085863..86543-681WP_001188930.1copper response regulator transcription factor PcoR-
MRY16398_RS2942586598..87527-930WP_000998778.1copper resistance inner membrane protein PcoD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..224544224544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15042.32 Da        Isoelectric Point: 7.2449

>T32083 WP_047368852.1 NZ_AP018757:c82469-82053 [Metakosakonia sp. MRY16-398]
VNKTYMLDTNICSLIMREQPEAVLKRLEQAVLRNHRTVISAITYQEMRSGATGPKASPRHIALVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAVAAGAILVTNNTREFERVPGLVLEDWVN

Download         Length: 417 bp

>T32083 NZ_AP018757:c82469-82053 [Metakosakonia sp. MRY16-398]
GTGAACAAAACGTATATGCTGGACACTAACATCTGCTCATTAATCATGCGCGAGCAACCGGAAGCGGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCAACCACCGCACTGTGATCTCGGCCATCACCTACCAGGAGATGCGCTCCGGCGCCACGGGCC
CGAAGGCTTCGCCGCGCCATATTGCGCTGGTTGATGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCG
GCGGTCGACGCTACCACGGACATCCGGGTGGCGCTGCGCCTCGCAGGCACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCATGCGGTTGCCGCCGGCGCCATCCTGGTGACCAACAATACAAGAGAGTTTGAACGGGTTCCGGGTCTGGTGCTGG
AAGACTGGGTAAATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8780.97 Da        Isoelectric Point: 4.6583

>AT32083 WP_047368851.1 NZ_AP018757:c82696-82466 [Metakosakonia sp. MRY16-398]
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIVREGDRIILRPVRPTWGSFAKMEKADPDFMAEREDVVSDEGRVDL

Download         Length: 231 bp

>AT32083 NZ_AP018757:c82696-82466 [Metakosakonia sp. MRY16-398]
ATGAGAACCGTATCTATTTTCAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGTGACATGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGAGACCGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGAAGATGG
AAAAAGCAGACCCGGACTTTATGGCGGAGCGTGAGGACGTTGTCAGTGACGAAGGACGGGTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A348DMH6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A348DMH7

References