32082

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 5521478..5522141 Replicon chromosome
Accession NZ_AP018756
Organism Metakosakonia sp. MRY16-398

Toxin (Protein)


Gene name tad Uniprot ID A0A348DL83
Locus tag MRY16398_RS27045 Protein ID WP_039077908.1
Coordinates 5521478..5521822 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A348DL84
Locus tag MRY16398_RS27050 Protein ID WP_071194355.1
Coordinates 5521824..5522141 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRY16398_RS26980 5516862..5517065 + 204 WP_125125527.1 hypothetical protein -
MRY16398_RS26985 5517062..5517253 + 192 WP_125125528.1 hypothetical protein -
MRY16398_RS26990 5517250..5517672 + 423 WP_125125529.1 hypothetical protein -
MRY16398_RS26995 5517861..5518055 + 195 WP_125125530.1 hypothetical protein -
MRY16398_RS27000 5518048..5518401 + 354 WP_125125531.1 hypothetical protein -
MRY16398_RS27005 5518409..5518627 + 219 WP_125125736.1 hypothetical protein -
MRY16398_RS27015 5518858..5519274 + 417 WP_125125533.1 hypothetical protein -
MRY16398_RS27020 5519274..5519498 + 225 WP_125125534.1 hypothetical protein -
MRY16398_RS27025 5519698..5519922 + 225 WP_125124565.1 hypothetical protein -
MRY16398_RS27030 5519919..5520143 + 225 WP_125125535.1 hypothetical protein -
MRY16398_RS27035 5520304..5520750 + 447 WP_125125536.1 hypothetical protein -
MRY16398_RS30760 5520743..5520889 + 147 WP_172600693.1 hypothetical protein -
MRY16398_RS27040 5520897..5521148 + 252 WP_125125537.1 pyocin activator PrtN family protein -
MRY16398_RS27045 5521478..5521822 + 345 WP_039077908.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MRY16398_RS27050 5521824..5522141 + 318 WP_071194355.1 helix-turn-helix domain-containing protein Antitoxin
MRY16398_RS27055 5522183..5523499 - 1317 WP_039077910.1 conjugal transfer protein TraF -
MRY16398_RS27060 5523772..5524287 + 516 WP_039077912.1 zinc uptake transcriptional repressor Zur -
MRY16398_RS27065 5524395..5524604 - 210 WP_039077936.1 CsbD family protein -
MRY16398_RS27070 5524702..5524890 + 189 WP_071194358.1 hypothetical protein -
MRY16398_RS27075 5524865..5525479 - 615 WP_039077914.1 transcriptional repressor LexA -
MRY16398_RS27080 5525588..5525956 - 369 WP_079497650.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5478546..5529493 50947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12655.46 Da        Isoelectric Point: 9.5820

>T32082 WP_039077908.1 NZ_AP018756:5521478-5521822 [Metakosakonia sp. MRY16-398]
MKPLYWVGSSKKDLQSLPEDVQDVFGYALHLAQDGGKHPQAKPLKGFGGAGVLEVVEDYCTDTYRAVYTLKFRQAVYVLH
AFQKKSSSGMQTPKSDIEKIRERLKAAEAHARGA

Download         Length: 345 bp

>T32082 NZ_AP018756:5521478-5521822 [Metakosakonia sp. MRY16-398]
ATGAAGCCACTGTATTGGGTGGGGAGCAGCAAAAAAGATCTTCAGTCTCTGCCGGAGGATGTTCAGGATGTTTTTGGTTA
TGCGTTGCATCTCGCACAAGACGGAGGTAAGCATCCCCAGGCAAAACCGTTAAAAGGATTTGGGGGCGCAGGTGTGCTGG
AGGTGGTCGAAGACTATTGCACCGATACTTATCGCGCGGTTTATACCCTGAAATTCAGACAGGCGGTCTATGTGCTACAT
GCATTTCAGAAGAAGTCGTCATCCGGTATGCAAACCCCCAAATCTGATATAGAAAAAATTCGAGAACGTCTTAAGGCAGC
AGAAGCCCATGCCAGAGGAGCATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11644.64 Da        Isoelectric Point: 11.1929

>AT32082 WP_071194355.1 NZ_AP018756:5521824-5522141 [Metakosakonia sp. MRY16-398]
MSQNIDISSGNVYADIGLDNADEMQVKAQLATTIGNIIKSRRLTQVEAAKLLGMTQPRLSNMLRGQFRGISEVKMLECLT
RLGRDVQIVVGRPRRTPGRMKVVFA

Download         Length: 318 bp

>AT32082 NZ_AP018756:5521824-5522141 [Metakosakonia sp. MRY16-398]
ATGAGCCAGAATATCGATATCAGCAGCGGCAATGTTTATGCCGACATTGGACTGGACAATGCGGATGAAATGCAGGTTAA
AGCGCAGCTTGCTACCACCATTGGCAATATCATTAAAAGTCGTCGTCTTACTCAGGTGGAGGCGGCAAAGTTATTGGGGA
TGACACAGCCCAGGCTATCAAATATGCTGCGCGGCCAATTTCGCGGCATAAGTGAAGTAAAAATGCTTGAATGTCTGACA
CGCTTAGGGCGCGATGTTCAAATTGTGGTTGGGCGCCCGCGCCGTACCCCGGGACGTATGAAGGTGGTTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348DL83

Antitoxin

Source ID Structure
AlphaFold DB A0A348DL84

References