Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4529772..4530391 Replicon chromosome
Accession NZ_AP018756
Organism Metakosakonia sp. MRY16-398

Toxin (Protein)


Gene name Hha Uniprot ID A0A348DII6
Locus tag MRY16398_RS22250 Protein ID WP_041852465.1
Coordinates 4530173..4530391 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A348DII5
Locus tag MRY16398_RS22245 Protein ID WP_041852464.1
Coordinates 4529772..4530146 (+) Length 125 a.a.

Genomic Context

MRY16398_RS22235MRY16398_RS22240MRY16398_RS22245MRY16398_RS22250MRY16398_RS22255MRY16398_RS22260MRY16398_RS22270MRY16398_RS22265MRY16398_RS22275MRY16398_RS22280
Location: 4524883..4526079 (1197 bp)
Type: Others
Protein ID: WP_041852462.1
Location: 4526102..4529251 (3150 bp)
Type: Others
Protein ID: WP_125125202.1
Location: 4529772..4530146 (375 bp)
Type: Antitoxin
Protein ID: WP_041852464.1
Location: 4530173..4530391 (219 bp)
Type: Toxin
Protein ID: WP_041852465.1
Location: 4530460..4531026 (567 bp)
Type: Others
Protein ID: WP_125125203.1
Location: 4531126..4531593 (468 bp)
Type: Others
Protein ID: WP_041852467.1
Location: 4533116..4533817 (702 bp)
Type: Others
Protein ID: WP_041852469.1
Location: 4531571..4533016 (1446 bp)
Type: Others
Protein ID: WP_125125204.1
Location: 4533814..4533954 (141 bp)
Type: Others
Protein ID: WP_006818844.1
Location: 4533958..4534218 (261 bp)
Type: Others
Protein ID: WP_041852470.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MRY16398_RS222354524883..4526079+1197WP_041852462.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
MRY16398_RS222404526102..4529251+3150WP_125125202.1multidrug efflux RND transporter permease subunit AcrB-
MRY16398_RS222454529772..4530146+375WP_041852464.1Hha toxicity modulator TomBAntitoxin
MRY16398_RS222504530173..4530391+219WP_041852465.1hemolysin expression modulator HhaToxin
MRY16398_RS222554530460..4531026+567WP_125125203.1maltose O-acetyltransferase-
MRY16398_RS222604531126..4531593+468WP_041852467.1membrane protein-
MRY16398_RS222654531571..4533016-1446WP_125125204.1PLP-dependent aminotransferase family protein-
MRY16398_RS222704533116..4533817+702WP_041852469.1GNAT family N-acetyltransferase-
MRY16398_RS222754533814..4533954-141WP_006818844.1type B 50S ribosomal protein L36-
MRY16398_RS222804533958..4534218-261WP_041852470.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8685.14 Da        Isoelectric Point: 8.9039

>T32081 WP_041852465.1 NZ_AP018756:4530173-4530391 [Metakosakonia sp. MRY16-398]
MSDKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELPDHELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T32081 NZ_AP018756:4530173-4530391 [Metakosakonia sp. MRY16-398]
ATGTCTGATAAGCCATTAACCAAAATTGATTATTTGATGCGATTACGACGTTGTCAGACAATTGACACGCTCGAACGCGT
TATTGAAAAAAATAAATACGAACTGCCTGACCATGAACTGACGGTGTTTTATTCAGCAGCCGATCATCGTCTGGCTGAGC
TAACCATGAATAAACTGTATGACAAAATCCCTCCTTCTGTGTGGAAATTCGTACGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14600.44 Da        Isoelectric Point: 5.5072

>AT32081 WP_041852464.1 NZ_AP018756:4529772-4530146 [Metakosakonia sp. MRY16-398]
MDEYSPKRHDIAQLKFLCETLYHDCLLNLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT32081 NZ_AP018756:4529772-4530146 [Metakosakonia sp. MRY16-398]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGCTTAAATTTCTCTGCGAAACGTTGTACCATGATTGTCTCCT
GAATCTTGAAGAAAGCCATCATGGATGGGTTAACGATCCTACTTCGGCAATCAATTTGCAGTTAAATGAGTTGATTGAAC
ATATAGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAAGATAATAAACTGATTGAGCAGATAGACGAATACCTT
GATGATACGTTTATGCTGTTCAGTAGCTACGGTATCAACACACAAGACTTGCAGAAATGGCGTAAATCGGGAAACCGATT
GTTCCGCTGTTTCGTCAATGTGAGCAAGGCTAACCCTGTTAGTCACTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A348DII6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A348DII5

References