Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3000691..3001613 Replicon chromosome
Accession NZ_AP018756
Organism Metakosakonia sp. MRY16-398

Toxin (Protein)


Gene name - Uniprot ID A0A348DED3
Locus tag MRY16398_RS14805 Protein ID WP_039079059.1
Coordinates 3001137..3001613 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A348DED2
Locus tag MRY16398_RS14800 Protein ID WP_071194172.1
Coordinates 3000691..3001137 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRY16398_RS14790 2996364..2999411 - 3048 WP_125124690.1 formate dehydrogenase-N subunit alpha -
MRY16398_RS14795 2999744..3000625 + 882 WP_125124691.1 aromatic amino acid DMT transporter YddG -
MRY16398_RS14800 3000691..3001137 + 447 WP_071194172.1 DUF2384 domain-containing protein Antitoxin
MRY16398_RS14805 3001137..3001613 + 477 WP_039079059.1 RES family NAD+ phosphorylase Toxin
MRY16398_RS14810 3001597..3003099 - 1503 WP_125124692.1 MFS transporter -
MRY16398_RS14815 3003212..3003802 + 591 WP_125124693.1 TetR family transcriptional regulator -
MRY16398_RS14820 3003784..3004626 - 843 WP_125124694.1 N-hydroxyarylamine O-acetyltransferase -
MRY16398_RS14825 3004702..3006357 - 1656 WP_125124695.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(5-150)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(28-90)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 17725.30 Da        Isoelectric Point: 5.2290

>T32072 WP_039079059.1 NZ_AP018756:3001137-3001613 [Metakosakonia sp. MRY16-398]
METVTFWRLVKERYALTAFDGYGARTFGGRWNSPGHECVYLGESKALCVLETLVHLEIEDIAQGYCFLTLDVPRNLIATL
DLTALPEDWKADPPPVSTQHIGDEWLASKQNGLVLRVPSTITGEWNALFNPEHPQAAKVLKSVKSEPFMLDPRLSRPC

Download         Length: 477 bp

>T32072 NZ_AP018756:3001137-3001613 [Metakosakonia sp. MRY16-398]
ATGGAAACTGTCACCTTCTGGCGTCTGGTCAAAGAACGCTATGCGCTGACCGCCTTCGACGGTTACGGCGCGCGAACCTT
TGGCGGACGCTGGAATTCACCGGGGCATGAATGCGTCTACCTGGGTGAATCAAAAGCTCTCTGCGTGCTGGAAACACTGG
TACATCTTGAGATTGAAGATATCGCCCAGGGCTACTGTTTCTTAACCCTCGATGTACCACGTAATCTTATCGCGACGCTG
GATTTGACCGCCCTGCCCGAAGACTGGAAAGCTGACCCGCCGCCTGTTTCCACGCAACACATCGGCGATGAGTGGCTGGC
ATCAAAGCAAAACGGGCTGGTACTGCGCGTCCCCAGTACCATCACCGGCGAATGGAACGCGCTGTTTAACCCCGAACACC
CACAGGCGGCGAAAGTCCTCAAAAGCGTAAAGTCCGAACCCTTTATGCTGGATCCCCGTCTTAGCCGTCCTTGCTAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 15690.07 Da        Isoelectric Point: 8.9810

>AT32072 WP_071194172.1 NZ_AP018756:3000691-3001137 [Metakosakonia sp. MRY16-398]
MQLYTPGVRAIPHDLLSILGLPATAIAAHDSINAGLSAGVLRDIAGAVSLDEITLCRMAGIDRNTYSRRLNSAEKRFSPE
QSARVYTLARVISAARELFEGDSERMATWLNKPAKGLGGKKPAELLSTPAGAEAVLTLIGRLEHGVIG

Download         Length: 447 bp

>AT32072 NZ_AP018756:3000691-3001137 [Metakosakonia sp. MRY16-398]
ATGCAACTCTATACACCGGGCGTACGCGCGATCCCGCACGACCTGCTCAGCATCCTGGGGCTGCCCGCCACGGCGATTGC
CGCTCATGACAGCATTAATGCCGGTCTGAGTGCAGGTGTGTTGCGTGATATCGCTGGCGCCGTCTCTCTTGATGAAATCA
CGCTGTGCCGAATGGCTGGCATTGATCGTAATACCTATAGCCGCAGGCTTAACAGCGCGGAAAAACGCTTTTCACCAGAA
CAGAGTGCGCGCGTCTACACGCTGGCACGAGTGATCAGCGCCGCTCGTGAGTTATTTGAAGGTGACAGCGAGCGTATGGC
CACCTGGCTCAATAAACCCGCGAAAGGCCTTGGCGGTAAAAAACCCGCAGAGCTTCTCTCGACACCCGCCGGTGCGGAAG
CGGTACTGACATTGATTGGTCGCCTTGAGCATGGTGTGATCGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348DED3

Antitoxin

Source ID Structure
AlphaFold DB A0A348DED2

References