Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2029563..2030153 Replicon chromosome
Accession NZ_AP018756
Organism Metakosakonia sp. MRY16-398

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MRY16398_RS09690 Protein ID WP_125124239.1
Coordinates 2029821..2030153 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MRY16398_RS09685 Protein ID WP_125124238.1
Coordinates 2029563..2029820 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRY16398_RS09655 2025170..2025505 - 336 WP_041851877.1 gamma-glutamylcyclotransferase -
MRY16398_RS09660 2025632..2025922 - 291 WP_079496374.1 DUF3601 domain-containing protein -
MRY16398_RS09665 2026180..2026719 - 540 WP_079496546.1 ester cyclase -
MRY16398_RS09675 2027018..2028127 - 1110 WP_125124236.1 alkene reductase -
MRY16398_RS09680 2028228..2029139 + 912 WP_125124237.1 LysR family transcriptional regulator -
MRY16398_RS09685 2029563..2029820 + 258 WP_125124238.1 antitoxin Antitoxin
MRY16398_RS09690 2029821..2030153 + 333 WP_125124239.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MRY16398_RS09700 2030554..2031987 + 1434 WP_103245488.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
MRY16398_RS09710 2032272..2032499 - 228 WP_125124240.1 hypothetical protein -
MRY16398_RS09715 2032716..2034176 + 1461 WP_125124241.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(5-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11781.49 Da        Isoelectric Point: 6.9812

>T32069 WP_125124239.1 NZ_AP018756:2029821-2030153 [Metakosakonia sp. MRY16-398]
MDRGEIWLVSLDPTTGHEQSGKRPVLIVSPASFNALTRLPVVVPVTSGGNFARAAGFAVSLEGAGTKTTGVIRCDQPRTI
DMDARNDKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T32069 NZ_AP018756:2029821-2030153 [Metakosakonia sp. MRY16-398]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCGACCACCGGGCATGAACAAAGCGGAAAACGTCCAGTGCTTAT
CGTTTCTCCCGCGTCATTTAATGCACTCACCCGTTTGCCCGTTGTTGTTCCGGTCACCAGTGGCGGAAACTTTGCCCGAG
CGGCGGGTTTTGCCGTCTCACTGGAAGGTGCGGGAACGAAAACCACGGGTGTGATTCGCTGCGATCAGCCCAGAACCATT
GATATGGACGCCCGAAACGACAAGCGTCTGGAACGTATACCCGATGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9272.74 Da        Isoelectric Point: 4.5799

>AT32069 WP_125124238.1 NZ_AP018756:2029563-2029820 [Metakosakonia sp. MRY16-398]
MYIARLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIENGCLIIEPQKRPHYSLEELLAQCDPHAEISEEDRQWIDGPAA
GKELL

Download         Length: 258 bp

>AT32069 NZ_AP018756:2029563-2029820 [Metakosakonia sp. MRY16-398]
ATGTATATCGCTCGCCTTAAAAAGGTTGGAGGATCCGTCATGCTGGCGGTTCCTCCTGCCGTATTGAAAACCCTGGGGCT
GTCGACGGATAGCGAAGTGGGTATGACCATTGAGAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCACATTACTCGC
TTGAGGAATTGCTGGCGCAGTGTGATCCGCACGCCGAAATCAGCGAAGAGGATCGGCAATGGATTGATGGGCCTGCGGCG
GGCAAGGAGCTTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References